Gamma delta lymphoma: a pictorial review of F-18 fluorodeoxyglucose PET/CT findings and a brief review of the literature

Author:

Rayamajhi Sampanna J1ORCID,Ponisio Maria R2,Mehta-Shah Neha3

Affiliation:

1. Division of Nuclear Medicine, The Icahn School of Medicine at Mount Sinai , New York, NY 10029, United States

2. Division of Nuclear Medicine, Washington University Medical School , 510 S Kingshighway Blvd Ste 7 , Saint Louis, MO 63110, United States

3. Division of Oncology, Washington University Medical School , 660 S Euclid Ave , Saint Louis, MO 63110, United States

Abstract

Abstract Gamma Delta (γδ) T-cell lymphomas are uncommon and aggressive neoplasms originating from the γδ receptor-bearing lymphocytes. The most frequent entities include primary hepatosplenic γδ T-cell lymphomas, primary cutaneous γδ lymphoma, and monomorphic epitheliotropic T-cell lymphoma. F-18 fluorodeoxyglucose (FDG) PET/CT is an important modality in the staging of Hodgkin’s and various non-Hodgkin’s lymphoma. However, literature is scare on imaging findings of γδ lymphoma on F-18 FDG PET/CT. In this review, we discuss briefly the clinical and biological features and present the spectrum of F-18 FDG PET/CT findings of γδ lymphoma.

Publisher

Oxford University Press (OUP)

Subject

Radiology, Nuclear Medicine and imaging,General Medicine

Reference15 articles.

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3. The restricted expression of granzyme M in human lymphocytes;Sayers;J Immunol,2001

4. The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression;Chattopadhyay;J Leukoc Biol,2009

5. Gamma-delta T-cell lymphomas;Tripodo;Nat Rev Clin Oncol,2009

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