Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications

Author:

Barash Uri1,Lapidot Moshe2,Zohar Yaniv3,Loomis Cynthia4,Moreira Andre4,Feld Sari1,Goparaju Chandra4,Yang Haining5,Hammond Edward6,Zhang Ganlin7,Li Jin-Ping8,Ilan Neta1,Nagler Arnon9,Pass Harvey I4,Vlodavsky Israel1

Affiliation:

1. Cancer and Vascular Biology Research Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel

2. Departments of General Thoracic Surgery, Rambam Health Care Campus, Haifa, Israel

3. Departments of Pathology Rambam Health Care Campus, Haifa, Israel

4. Department of Cardiothoracic Surgery, Langone Medical Center, New York University School of Medicine, New York, NY

5. University of Hawaii Cancer Center, Honolulu, HI

6. Zucero Therapeutics, Darra, Queensland, Australia

7. Beijing Hospital of Traditional Chinese Medicine, Beijing, China

8. Department of Medical Biochemistry and Microbiology, University of Uppsala, Uppsala, Sweden

9. Department of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Israel

Funder

Israel Science Foundation

United States-Israel Binational Science Foundation

Israel Cancer Research Fund

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Reference45 articles.

1. Functions of cell surface heparan sulfate proteoglycans;Bernfield;Annu Rev Biochem,1999

2. Supramolecular assembly of basement membranes;Timpl;Bioessays.,1996

3. Heparan sulphate proteoglycans: The sweet side of development;Udo Hacker KNaNP;Nat Rev Mol Cell Biol.,2005

4. Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis;Vlodavsky;Nat Med.,1999

5. Proteoglycans in health and disease: New concepts for heparanase function in tumor progression and metastasis;Barash;Febs J.,2010

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