PHOX2B as a Reliable Marker for Neuroblastoma in Tissue and Cytology Specimens-Reference-Cited by-全球学者库

PHOX2B as a Reliable Marker for Neuroblastoma in Tissue and Cytology Specimens

Published:2021-12-01 Issue:12 Volume:80 Page:1108-1116
ISSN:0022-3069
Container-title:Journal of Neuropathology & Experimental Neurology
language:en
Short-container-title:

Author:

Ma Yangyang¹,Feng Jiayan²,Zhao Jing¹,Ding Di¹,Tian Feng¹,Chen Lian¹,Zheng Jicui²,Xiao Xianmin²

Affiliation:

1. From the Department of Pathology, Children’s Hospital of Fudan University (National Children’s Medical Center), Shanghai, China

2. Department of Surgery, Children’s Hospital of Fudan University (National Children’s Medical Center), Shanghai, China

Abstract

Abstract To investigate the diagnostic utility of immunohistochemistry for paired-like homeobox 2B (PHOX2B) expression in neuroblastomas (NBs) and tumors that mimic them, tissue samples (n = 229) from 157 cases of NB, 210 central nervous system tumors, and 170 extracranial non-NB solid tumors (n = 170) were immunostained for PHOX2B. Additionally, PHOX2B expression in 67 body fluid cytology specimens was analyzed. In tissue specimens, PHOX2B expression was positive in NBs, pheochromocytomas, and paragangliomas but negative in all of the other tumors evaluated. PHOX2B was detected by immunohistochemistry in 5 NB cytology specimens; all of the others were negative. These results suggest that PHOX2B may be a sensitive and specific immunohistochemical marker for the pathological diagnosis and differential diagnosis of NB in both tissue and cytology specimens.

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Neurology (clinical),Neurology,General Medicine,Pathology and Forensic Medicine

Link

https://academic.oup.com/jnen/article-pdf/80/12/1108/41974403/nlab112.pdf

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