Perfluorocarbon solutions limit tubular epithelial cell injury and promote CD133+ kidney progenitor differentiation: potential use in renal assist devices for sepsis-associated acute kidney injury and multiple organ failure

Author:

Cantaluppi Vincenzo12,Medica Davide2,Quercia Alessandro Domenico12,Dellepiane Sergio2,Figliolini Federico2,Virzì Grazia Maria3,Brocca Alessandra3,Quaglia Marco1,Marengo Marita4,Olivieri Carlo5,Senzolo Mara3,Garzotto Francesco3,Della Corte Francesco5,Castellano Giuseppe6,Gesualdo Loreto6,Camussi Giovanni2,Ronco Claudio3

Affiliation:

1. Nephrology, Dialysis and Kidney Transplantation Unit, Maggiore della Carità Hospital—University of Eastern Piedmont, Novara, Italy

2. Department of Medical Sciences and Center for Experimental Medical Research (CeRMS), Nephrology, Dialysis and Kidney Transplantation Center, University of Torino, Torino, Italy

3. Nephrology, Dialysis and Kidney Transplantation Unit, San Bortolo Hospital and International Renal Research Institute Vicenza (IRRIV), Vicenza, Italy

4. Nephrology and Dialysis Unit, ASLCN1, Cuneo, Italy

5. Intensive Care Unit, Maggiore della Carità Hospital—University of Eastern Piedmont, Novara, Italy

6. Nephrology, Dialysis and Kidney Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy

Funder

Bando Ricerca Indipendente

Italian Society of Nephrology and Bando sulla medicina Translazionale

Department of Translational Medicine

University of Eastern Piedmont

Publisher

Oxford University Press (OUP)

Subject

Transplantation,Nephrology

Reference50 articles.

1. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients;Chertow;J Am Soc Nephrol,2005

2. Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes. Clin;Bagshaw;J Am Soc Nephrol,2007

3. [New mechanisms and recent insights in the pathogenesis of acute kidney injury (AKI)];Cantaluppi;G Ital Nefrol,2012

4. Detrimental cross-talk between sepsis and acute kidney injury: new pathogenic mechanisms, early biomarkers and targeted therapies;Dellepiane;Crit Care,2016

5. Pathophysiology and management of septic acute kidney injury;Romanovsky;Pediatr Nephrol,2014

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