Postvaccination Symptoms After a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease: Results From CORALE-IBD

Author:

Li Dalin1,Debbas Philip1,Mujukian Angela1,Cheng Susan2,Braun Jonathan1ORCID,McGovern Dermot P B1,Melmed Gil Y1ORCID,Banty Andrea1,Feldman Edward1,Ha Christina1,Lee Susie1,Rabizadeh Shervin1,Stein Theodore1,Solomon Theodore1,Syal Gaurav1,Targan Stephan1,Vasiliauskas Eric1,Ziring David1,Bonthala Niru1,Botwin Gregory S1,Hampton Melissa1,Mengesha Emebet1,Khanishian Elizabeth1,Pozdnyakova Valeriya1,Gu Phillip1,White Shane1,Zamudio Cindy1,Gonzalez Daniel1,Parry Alyssa1,Hanna Mary1,Chan Justin1,Ebinger Joe2,Joung Sandy2,Wu Min2,Hoang Amy2,Wynter Timothy2,Sun Nancy2,Figueiredo Jane C3,Merchant Akil3,Merin Noah3,Reckamp Karen L3,Appel Keren4,Kumar Rashmi5,Boland Brigid6,Charabaty Aline7,Chiorean Michael8,Cohen Erica9,Flynn Ann10,Valentine John10,Ehrlich Adam C11,Fudman David12,Horizon Arash13,Karayev Dmitry13,Kretzmann Benjamin13,Hou Jason14,Hwang Caroline15,Lazarev Mark16,Lum Donald17,Fausel Rebecca17,Reddy Swapna17,McConnell Ryan18,Mattar Mark C19,Metwally Mark20,Ostrov Arthur20,Parekh Nimisha21,Raffals Laura22,Rubin David T23,Sheibani Sarah24,Siegel Corey A25,Wolf Douglas26,Younes Ziad27,Damas Oriana28,

Affiliation:

1. Inflammatory Bowel and Immunobiology Research Institute, Karsh Division of Digestive and Liver Diseases, Department of Medicine, Cedars-Sinai Medical Center , Los Angeles, CA , USA

2. Smidt Heart Institute, Department of Medicine, Cedars-Sinai , Los Angeles, CA , USA

3. Samual Oschin Comprehensive Cancer Institute, Cedars-Sinai , Los Angeles, CA , USA

4. Children’s Hospital , Orange County, CA , USA

5. Banner University Medical Center , Phoenix, AZ , USA

6. University of California , San Diego, CA , USA

7. Sibley Memorial Hospital, Johns Hopkins , Washington, DC , USA

8. Swedish Medical Center , Seattle, WA , USA

9. Capital Digestive Care , Chevy Chase, MD , USA

10. University of Utah , Salt Lake City, UT , USA

11. Temple University , Philadelphia, PA , USA

12. UT Southwestern , Dallas, TX , USA

13. Center for Rheumatology , Los Angeles, CA , USA

14. Baylor College of Medicine , Houston, TX , USA

15. Hoag Hospital, Newport Beach , CA , USA

16. Johns Hopkins Hospital , Baltimore, MD , USA

17. The Oregon Clinic , Portland, OR , USA

18. Sutter Health , Palo Alto, CA , USA

19. Medstar-Georgetown , Washington, DC , USA

20. Saratoga-Schenectady Gastroenterology , Saratoga Springs, NY , USA

21. University of California , Irvine, CA , USA

22. The Mayo Clinic , Rochester, MN , USA

23. University of Chicago , Chicago, IL , USA

24. Keck Medicine of University of Southern California , Los Angeles, CA , USA

25. Dartmouth-Hitchcock Medical Center , Lebanon, NH , USA

26. Atlanta Gastroenterology Associates , Atlanta, GA , USA

27. Gastro One , Germantown, TN , USA

28. University of Miami , Miami, FL , USA

Abstract

Abstract Background The safety of a third dose of SARS-CoV-2 mRNA vaccination in patients with inflammatory bowel disease is unknown. Methods We compared symptoms following a third SARS-CoV-2 mRNA vaccine dose with symptoms after the second dose in IBD. Results The study group included 594 patients (70% female, 58% BNT162b2). Overall, 41% reported symptoms after a third dose. Symptom frequency and severity were lower after the third dose relative to the second dose for every organ system, except for gastrointestinal symptoms which were marginally worse. Conclusion The frequency and severity of symptoms after a third mRNA vaccine dose are generally similar or milder than after a second dose for most organ systems.

Funder

Leona M. and Harry B. Helmsley Charitable Trust

Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute

National Institute of Diabetes and Digestive and Kidney Diseases

Cedars-Sinai Precision Health Initiative

Erika J. Glazer Family Foundation

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,Immunology and Allergy

Reference9 articles.

1. COVID-19 vaccination intent and perceptions among patients with inflammatory bowel diseases;Dalal;Clin Gastroenterol Hepatol.,2021

2. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine;Baden;N Engl J Med.,2021

3. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine;Polack;N Engl J Med.,2020

4. Adverse events following SARS-CoV-2 mRNA vaccination: among patients with inflammatory bowel disease;Botwin;Am J Gastroenterol.,2021

5. Impact of SARS-CoV-2 vaccination on inflammatory bowel disease activity and development of vaccine-related adverse events: results from Prevent-Covid;Weaver;Inflamm Bowel Dis.,2021

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