Environmental Interaction of Resolved Human Cytomegalovirus Infection With Crohn’s Disease Location-Reference-Cited by-同舟云学术

Environmental Interaction of Resolved Human Cytomegalovirus Infection With Crohn’s Disease Location

Published:2022-12-12 Issue:2 Volume:29 Page:328-331
ISSN:1078-0998
Container-title:Inflammatory Bowel Diseases
language:en
Short-container-title:

Author:

Shih Terri¹,Yusung Susy¹,Gonsky Rivkah²,Dutra-Clarke Rhiannon²,Ziring David²,Rabizadeh Shervin²,Kugathasan Subra³^ORCID,Denson Lee A⁴,Li Dalin²,Braun Jonathan²^ORCID

Affiliation:

1. David Geffen UCLA School of Medicine , Los Angeles, CA, 90095 , USA

2. Cedars-Sinai Medical Center , Los Angeles, CA, 90048 , USA

3. Emory University School of Medicine , Atlanta, GA, 30322 , USA

4. Cincinnati Children’s Medical Center , Cincinnati, OH, 45229 , USA

Abstract

Lay Summary Active cytomegalovirus (CMV) infection complicates management of inflammatory bowel disease, but the relationship of resolved CMV infection to Crohn’s disease (CD) behavior or localization is unknown. This article reports a striking risk (9-fold) of Crohn’s disease localization to the colon with prior CMV infection. It also reports imputed mucosal cellular composition, HLA class 1, and KIR gene variants that delimit prior observations regarding HLA and KIR associations with Crohn’s disease risk and behavior.

Funder

Crohn's and Colitis Foundation

National Center for Advancing Translational Sciences

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,Immunology and Allergy

Link

https://academic.oup.com/ibdjournal/advance-article-pdf/doi/10.1093/ibd/izac251/47797849/izac251.pdf

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