Pharmacokinetics of cancer therapeutics and energy balance: the role of diet intake, energy expenditure, and body composition

Author:

Purcell Sarah A12,Kok Dieuwertje E3,Ketterl Tyler45,Garcia Miriam B6,Joffe Lenat7,Brown Justin C8,Dieli-Conwright Christina M910ORCID,Williams Grant R11

Affiliation:

1. Department of Medicine, Division of Endocrinology, University of British Columbia , Vancouver, Canada

2. Irving K. Barber Faculty of Science, Department of Biology, University of British Columbia Okanagan , Kelowna, Canada

3. Division of Human Nutrition and Health, Wageningen University & Research , Wageningen, the Netherlands

4. Division of Pediatric Hematology/Oncology and Bone Marrow Transplant, Department of Pediatrics, University of Washington , Seattle, WA, USA

5. Cancer and Blood Disorders Center, Seattle Children’s Hospital , Seattle, WA, USA

6. Division of Pediatrics, The University of Texas MD Anderson Cancer Center , Houston, TX, USA

7. Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Cohen Children’s Medical Center, Donald and Barbara Zucker School of Medicine at Hofstra, Northwell Health , New Hyde Park, NY, USA

8. Pennington Biomedical Research Center , Baton Rouge, LA, USA

9. Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, MA, USA

10. Harvard Medical School , Boston, MA, USA

11. Institute for Cancer Outcomes and Survivorship, Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham , Birmingham, AL, USA

Abstract

Abstract Energy balance accounts for an individual’s energy intake, expenditure, and storage. Each aspect of energy balance has implications for the pharmacokinetics of cancer treatments and may impact an individual’s drug exposure and subsequently its tolerance and efficacy. However, the integrated effects of diet, physical activity, and body composition on drug absorption, metabolism, distribution, and excretion are not yet fully understood. This review examines the existing literature on energy balance, specifically the role of dietary intake and nutritional status, physical activity and energy expenditure, and body composition on the pharmacokinetics of cancer therapeutics. As energy balance and pharmacokinetic factors can be influenced by age-related states of metabolism and comorbidities, this review also explores the age-related impact of body composition and physiologic changes on pharmacokinetics among pediatric and older adult populations with cancer.

Funder

National Cancer Institute

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

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