The use of serum methotrexate level as an assessment of biochemical drug adherence in psoriasis-Reference-Cited by-同舟云学术

The use of serum methotrexate level as an assessment of biochemical drug adherence in psoriasis

Published:2024-03-08 Issue:6 Volume:190 Page:927-929
ISSN:0007-0963
Container-title:British Journal of Dermatology
language:en
Short-container-title:

Author:

Ra Amelle G¹²^ORCID,Littlewood Zoe¹,Barton Anne²³^ORCID,Keevil Brian⁴,McTaggart Malcolm⁴,Warren Richard B¹²^ORCID,Bluett James²³^ORCID

Affiliation:

1. Dermatology Centre, Northern Care Alliance NHS Foundation Trust , Manchester, UK

2. NIHR Manchester Biomedical Research Centre , Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK

3. Versus Arthritis Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester , Manchester , UK

4. Clinical Biochemistry, Wythenshawe Hospital, Manchester University NHS Foundation Trust , Manchester Academic Health Science Centre, Manchester , UK

Abstract

Psoriasis is a common inflammatory skin condition affecting approximately 2–3% of people worldwide. Methotrexate (MTX) is a cheap and effective drug that is often recommended as the first-choice systemic agent for psoriasis. Around 40–50% of patients achieve a good response; however, mechanisms of nonresponse are poorly understood. It is not known whether biochemical MTX adherence in patients with psoriasis is suboptimal and requires intervention. Our aim was to audit biochemical MTX adherence using a sensitive liquid chromatography–tandem mass spectrometry in patients prescribed oral MTX for the treatment of psoriasis at our tertiary dermatology centre. Ethical approval for this audit was not required as confirmed by the Health Research Authority.

Funder

National Institute for Health

Versus Arthritis

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/bjd/advance-article-pdf/doi/10.1093/bjd/ljae096/57311707/ljae096.pdf

Reference8 articles.

1. P106: Feasibility study of methotrexate use improvement in rheumatoid arthritis using biomarker feedback: the MIRA Trial;Bluett;Rheumatology,2023

2. Safety and efficacy of methotrexate in psoriasis: a meta-analysis of published trials;West;PLoS ONE,2016

3. A sensitive LC-MS/MS methotrexate assay capable of assessing adherence to methotrexate therapy in rheumatoid arthritis;McTaggart;Clin Chem Lab Med,2023

4. Development and validation of a methotrexate adherence assay;Bluett;Ann Rheum Dis,2019

5. Translating research into clinical practice: quality improvement to halve non-adherence to methotrexate;Barton;Rheumatology,2021