A biomarker framework for cardiac aging: the Aging Biomarker Consortium consensus statement

Author:

,Zhang Weiwei1,Che Yang2,Tang Xiaoqiang3ORCID,Chen Siqi45,Song Moshi4567,Wang Li2ORCID,Sun Ai-Jun891011,Chen Hou-Zao12ORCID,Xu Ming1314,Wang Miao215,Pu Jun16ORCID,Li Zijian131718,Xiao Junjie1920,Cao Chun-Mei212223ORCID,Zhang Yan2425,Lu Yao26ORCID,Zhao Yingxin27,Wang Yan-Jiang28293031,Zhang Cuntai3233,Shen Tao34ORCID,Zhang Weiqi5735,Tao Ling36ORCID,Qu Jing56737,Tang Yi-Da38ORCID,Liu Guang-Hui456739ORCID,Pei Gang40,Li Jian34ORCID,Cao Feng1

Affiliation:

1. Department of Cardiology, The Second Medical Centre, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases , Beijing 100853 , China

2. State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100037 , China

3. Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University , Chengdu 610041 , China

4. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101 , China

5. University of Chinese Academy of Sciences , Beijing 100049 , China

6. Beijing Institute for Stem Cell and Regenerative Medicine , Beijing 100101 , China

7. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences , Beijing 100101 , China

8. Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases , Shanghai 200433 , China

9. Key Laboratory of Viral Heart Diseases, National Health Commission , Shanghai 200433 , China

10. Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences , Shanghai 200433 , China

11. Institutes of Biomedical Sciences, Fudan University , Shanghai 200032 , China

12. Department of Biochemistry and Molecular Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100005 , China

13. Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital , Beijing 100191 , China

14. NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University , Beijing 100191 , China

15. Clinical Pharmacology Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100037 , China

16. State Key Laboratory for Oncogenes and Related Genes, Department of Cardiology, Shanghai Jiao Tong University , Shanghai 200025 , China

17. Beijing Key Laboratory of Cardiovascular Receptors Research, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University , Beijing 100191 , China

18. Department of Pharmacy, Peking University Third Hospital , Beijing 100191 , China

19. Shanghai Engineering Research Center of Organ Repair, School of Medicine, Shanghai University , Shanghai 200444 , China

20. Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University , Shanghai 200444 , China

21. Laboratory of Cardiovascular Science, Beijing Clinical Research Institute, Beijing Friendship Hospital, Capital Medical University , Beijing 100050 , China

22. Capital Institute of Pediatrics , Beijing 100020 , China

23. Graduate School of Peking Union Medical College , Beijing 100730 , China

24. State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, College of Future Technology, Peking University , Beijing 100871 , China

25. Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, School of Basic Medical Sciences, Ministry of Education, Peking University Health Science Center , Beijing 100191 , China

26. Clinical Research Center, The Third Xiangya Hospital, Central South University , Changsha 410013 , China

27. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease , Beijing 100029 , China

28. Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University , Chongqing 400042 , China

29. Institute of Brain and Intelligence, Third Military Medical University , Chongqing 400042 , China

30. Chongqing Key Laboratory of Ageing and Brain Diseases , Chongqing 400016 , China

31. Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences , Shanghai 200031 , China

32. Gerontology Center of Hubei Province , Wuhan 430000 , China

33. Institute of Gerontology, Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030 , China

34. The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission , Beijing 100730 , China

35. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation , Beijing 100101 , China

36. Department of Cardiology, Xijing Hospital, the Fourth Military Medical University , Xi’an 710032 , China

37. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101 , China

38. Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Cardiovascular Receptors Research , Beijing 100191 , China

39. Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University , Beijing 100053 , China

40. Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-Based Biomedicine, The Collaborative Innovation Center for Brain Science, School of Life Sciences and Technology, Tongji University , Shanghai 200070 , China

Abstract

Abstract Cardiac aging constitutes a significant risk factor for cardiovascular diseases prevalent among the elderly population. Urgent attention is required to prioritize preventive and management strategies for age-related cardiovascular conditions to safeguard the well-being of elderly individuals. In response to this critical challenge, the Aging Biomarker Consortium (ABC) of China has formulated an expert consensus on cardiac aging biomarkers. This consensus draws upon the latest scientific literature and clinical expertise to provide a comprehensive assessment of biomarkers associated with cardiac aging. Furthermore, it presents a standardized methodology for characterizing biomarkers across three dimensions: functional, structural, and humoral. The functional dimension encompasses a broad spectrum of markers that reflect diastolic and systolic functions, sinus node pacing, neuroendocrine secretion, coronary microcirculation, and cardiac metabolism. The structural domain emphasizes imaging markers relevant to concentric cardiac remodeling, coronary artery calcification, and epicardial fat deposition. The humoral aspect underscores various systemic (N) and heart-specific (X) markers, including endocrine hormones, cytokines, and other plasma metabolites. The ABC’s primary objective is to establish a robust foundation for assessing cardiac aging, thereby furnishing a dependable reference for clinical applications and future research endeavors. This aims to contribute significantly to the enhancement of cardiovascular health and overall well-being among elderly individuals.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Reference134 articles.

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