Unlocking heart anti-aging potential: the SIRT2-STAT3-CDKN2B pathway as a bridge between fiction and reality
Author:
Affiliation:
1. State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University , Shanghai 200438, China
Funder
National Natural Science Foundation of China
Publisher
Oxford University Press (OUP)
Link
https://academic.oup.com/lifemedi/advance-article-pdf/doi/10.1093/lifemedi/lnae020/57567793/lnae020.pdf
Reference5 articles.
1. Protective effects of sirtuins in cardiovascular diseases: from bench to bedside;Winnik;Eur Heart J,2015
2. SIRT2 acts as a cardioprotective deacetylase in pathological cardiac hypertrophy;Tang;Circulation,2017
3. Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice;Zhang;Eur Heart J,2023
4. SIRT2-knockdown rescues GARS-induced Charcot-Marie-Tooth neuropathy;Zhao;Aging Cell,2021
5. SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B;Ye;Nat Aging,2023
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