Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions

Author:

Wen Patrick Y1,Weller Michael2ORCID,Lee Eudocia Quant1ORCID,Alexander Brian M1,Barnholtz-Sloan Jill S3,Barthel Floris P4,Batchelor Tracy T5,Bindra Ranjit S6,Chang Susan M7,Chiocca E Antonio8,Cloughesy Timothy F9,DeGroot John F10,Galanis Evanthia11,Gilbert Mark R12,Hegi Monika E13,Horbinski Craig14,Huang Raymond Y15,Lassman Andrew B16,Le Rhun Emilie17,Lim Michael18,Mehta Minesh P19,Mellinghoff Ingo K20,Minniti Giuseppe21,Nathanson David22,Platten Michael23,Preusser Matthias24,Roth Patrick2,Sanson Marc25,Schiff David26,Short Susan C27,Taphoorn Martin J B28,Tonn Joerg-Christian29,Tsang Jonathan22,Verhaak Roel G W4,von Deimling Andreas30,Wick Wolfgang31ORCID,Zadeh Gelareh32,Reardon David A1,Aldape Kenneth D33,van den Bent Martin J34

Affiliation:

1. Dana-Farber Cancer Institute, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

2. Department of Neurology and Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland

3. Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio, USA

4. The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA

5. Department of Neurology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Harvard Medical School

6. Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut, USA

7. University of California San Francisco, San Francisco, California, USA

8. Department of Neurosurgery, Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA

9. David Geffen School of Medicine, Department of Neurology, University of California Los Angeles, Los Angeles, California, USA

10. Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

11. Mayo Clinic, Rochester, Minnesota, USA

12. Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

13. Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

14. Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

15. Division of Neuroradiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

16. Department of Neurology and Herbert Irving Comprehensive Cancer Center, NewYork-Presbyterian Hospital/Columbia University Irving Medical Center, New York, New York, USA

17. University of Lille, Inserm, Neuro-oncology, General and Stereotaxic Neurosurgery service, University Hospital of Lille, Lille, France; Breast Cancer Department, Oscar Lambret Center, Lille, France and Department of Neurology & Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland

18. Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

19. Miami Cancer Institute, Miami, Florida, USA

20. Department of Neurology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA

21. Radiation Oncology Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy

22. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, USA

23. Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Heidelberg, Germany

24. Division of Oncology, Department of Medicine, Medical University of Vienna, Vienna, Austria

25. Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière – Charles Foix, Service de Neurologie 2-Mazarin, Paris, France

26. University of Virginia School of Medicine, Division of Neuro-Oncology, Department of Neurology, University of Virginia, Charlottesville, Virginia, USA

27. Leeds Institute of Medical Research at St James’s, University of Leeds, Leeds, UK

28. Department of Neurology, Medical Center Haaglanden, The Hague and Department of Neurology, Leiden University Medical Center, the Netherlands

29. Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany

30. Neuropathology and Clinical Cooperation Unit Neuropathology, University Heidelberg and German Cancer Center, Heidelberg, Germany

31. Department of Neurology and Neuro-oncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany

32. MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, Toronto, Canada

33. Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

34. Department of Neurology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands

Abstract

Abstract Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Neurology (clinical),Oncology

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