Brain metastases: A Society for Neuro-Oncology (SNO) consensus review on current management and future directions

Author:

Aizer Ayal A1ORCID,Lamba Nayan12,Ahluwalia Manmeet S3,Aldape Kenneth4,Boire Adrienne5ORCID,Brastianos Priscilla K6,Brown Paul D7,Camidge D Ross8,Chiang Veronica L9,Davies Michael A10,Hu Leland S11,Huang Raymond Y12,Kaufmann Timothy13,Kumthekar Priya14ORCID,Lam Keng15,Lee Eudocia Q8,Lin Nancy U8,Mehta Minesh16,Parsons Michael17ORCID,Reardon David A8,Sheehan Jason18,Soffietti Riccardo19ORCID,Tawbi Hussein10ORCID,Weller Michael20ORCID,Wen Patrick Y8

Affiliation:

1. Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women’s Hospital , Boston, Massachusetts , USA

2. Harvard Radiation Oncology Program , Boston, Massachusetts , USA

3. Department of Medical Oncology, Miami Cancer Institute , Miami, Florida , USA

4. Laboratory of Pathology, National Cancer Institute , Bethesda, Maryland , USA

5. Department of Neurology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center , New York, New York , USA

6. Departments of Neuro-Oncology and Medical Oncology, Massachusetts General Hospital , Boston, Massachusetts , USA

7. Department of Radiation Oncology, Mayo Clinic , Rochester, Minnesota , USA

8. Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, Massachusetts , USA

9. Departments of Neurosurgery and Radiation Oncology, Yale School of Medicine , New Haven, Connecticut , USA

10. Department of Melanoma Medical Oncology, MD Anderson Cancer Center , Houston, Texas , USA

11. Department of Radiology, Neuroradiology Division, Mayo Clinic , Phoenix, Arizona , USA

12. Department of Radiology, Brigham and Women’s Hospital , Boston, Massachusetts , USA

13. Department of Radiology, Mayo Clinic , Rochester, Minnesota , USA

14. Department of Neurology at The Feinberg School of Medicine at Northwestern University and The Malnati Brain Tumor Institute at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University , Chicago, Illinois , USA

15. Department of Neurology, Kaiser Permanente, Los Angeles Medical Center , Los Angeles, California , USA

16. Department of Radiation Oncology, Miami Cancer Institute , Miami, Florida , USA

17. Departments of Oncology and Psychiatry, Massachusetts General Hospital , Boston, Massachusetts , USA

18. Department of Neurosurgery, University of Virginia , Charlottesville, Virginia , USA

19. Division of Neuro-Oncology, Department of Neuroscience Rita Levi Montalcini, University of Turin , Turin , Italy

20. Department of Neurology, University Hospital and University of Zurich , Zurich , Switzerland

Abstract

Abstract Brain metastases occur commonly in patients with advanced solid malignancies. Yet, less is known about brain metastases than cancer-related entities of similar incidence. Advances in oncologic care have heightened the importance of intracranial management. Here, in this consensus review supported by the Society for Neuro-Oncology (SNO), we review the landscape of brain metastases with particular attention to management approaches and ongoing efforts with potential to shape future paradigms of care. Each coauthor carried an area of expertise within the field of brain metastases and initially composed, edited, or reviewed their specific subsection of interest. After each subsection was accordingly written, multiple drafts of the manuscript were circulated to the entire list of authors for group discussion and feedback. The hope is that the these consensus guidelines will accelerate progress in the understanding and management of patients with brain metastases, and highlight key areas in need of further exploration that will lead to dedicated trials and other research investigations designed to advance the field.

Funder

Varian Medical Systems

Astrazeneca

Abbvie

Bayer

Incyte

Pharmacyclics

Novocure

Merck

Novartis

Roswell Park Cancer Foundation

Velosano

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

AIM at Melanoma Foundation

NIH

NCI

American Cancer Society

Melanoma Research Alliance

Arizona Biomedical Research Commission

Agios Pharmaceuticals

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Neurology (clinical),Oncology

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