Radiomic subtyping improves disease stratification beyond key molecular, clinical, and standard imaging characteristics in patients with glioblastoma

Author:

Kickingereder Philipp1,Neuberger Ulf1,Bonekamp David2,Piechotta Paula L1,Götz Michael3,Wick Antje4,Sill Martin5,Kratz Annekathrin67,Shinohara Russell T8,Jones David T W910,Radbruch Alexander12,Muschelli John11,Unterberg Andreas12,Debus Jürgen1314,Schlemmer Heinz-Peter2,Herold-Mende Christel,Pfister Stefan91015,von Deimling Andreas67,Wick Wolfgang416,Capper David6717,Maier-Hein Klaus H3,Bendszus Martin1

Affiliation:

1. Department of Neuroradiology, University of Heidelberg Medical Center, Heidelberg, Germany

2. Department of Radiology, German Cancer Research Center, Heidelberg, Germany

3. Division of Medical Image Computing, German Cancer Research Center, Heidelberg, Germany

4. Neurology Clinic, University of Heidelberg Medical Center, Heidelberg, Germany

5. Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany

6. Department of Neuropathology, University of Heidelberg Medical Center, Heidelberg, Germany

7. German Cancer Consortium, Clinical Cooperation Unit Neuropathology, German Cancer Research Center, Heidelberg, Germany

8. Department of Biostatistics, Epidemiology, and Informatics, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

9. Division of Pediatric Neurooncology, German Cancer Research Center, Heidelberg, Germany

10. German Cancer Consortium Core Center Heidelberg, Heidelberg, Germany

11. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

12. Department of Neurosurgery, University of Heidelberg Medical Center, Heidelberg, Germany

13. Department of Radiation Oncology, University of Heidelberg Medical Center, Heidelberg Institute of Radiation Oncology and National Center for Radiation Research in Oncology, Heidelberg, Germany

14. Molecular and Translational Radiation Oncology, National Center for Tumor Diseases, Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany

15. Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital, Heidelberg, Germany

16. Clinical Cooperation Unit Neurooncology, German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany

17. Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute for Neuropathology, Berlin, Germany

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Clinical Neurology,Oncology

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