CMV-Specific T-cell Responses at Older Ages: Broad Responses With a Large Central Memory Component May Be Key to Long-term Survival

Author:

Bajwa Martha1,Vita Serena2,Vescovini Rosanna3,Larsen Martin45,Sansoni Paolo3,Terrazzini Nadia6,Caserta Stefano7,Thomas David1,Davies Kevin A.1,Smith Helen8,Kern Florian1

Affiliation:

1. Department of Clinical and Experimental Medicine,

2. Institute Pasteur, Cenci-Bolognetti Foundation, Department of Public Health and Infectious Diseases, University Sapienza of Rome, and

3. Dipartimento di Clinica Sperimentale, Università di Parma, Italy;

4. Inserm UMR-S1135, Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris), and

5. AP-HP, Groupement Hospitalier Pitié-Salpêtrière, Département d’Immunologie, Paris, France; and

6. School of Pharmacy and Biomolecular Sciences, University of Brighton, United Kingdom

7. Department of Global Health and Infection, and

8. Department of Primary Care and Public Health and Sussex Medical School, Brighton, United Kingdom;

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Reference37 articles.

1. Dysregulation of T-cell function in the elderly: scientific basis and clinical implications;Fulop;Drugs Aging,2005

2. Memory T cell homeostasis and senescence during aging;Akbar;Curr Opin Immunol,2005

3. Immunity and ageing in man: annual review 2006/2007;Pawelec;Exp Gerontol,2008

4. Comorbidity is a better predictor of impaired immunity than chronological age in older adults;Castle;J Am Geriatr Soc,2005

5. Immunosenescence of ageing;Gruver;J Pathol,2007

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