Human Papillomavirus Intermittence and Risk Factors Associated With First Detections and Redetections in the Ludwig-McGill Cohort Study of Adult Women
Author:
Malagón Talía1ORCID, Trottier Helen23, El-Zein Mariam1ORCID, Villa Luisa L45, Franco Eduardo L1, Paulo Sao, Baggio Maria Luiza, Galan Lenice, Sobrinho João Simão, Mann Prado José Carlos, Termini Lara, Costa Maria Cecília, Miyamura Romulo, Trevisan Andrea, Thomann Patricia, Candeias João, Sichero Laura, Rahal Paula, Ruiz Antonio, Kaiano Jane, Santos Monica, Savio Patricia, Maciag Paulo, Rabachini Tatiana, Ferreira Silvaneide, Villa Luisa, El-Zein Mariam, Rousseau Marie-Claude, Mahmud Salaheddin, Schlecht Nicolas, Trottier Helen, Richardson Harriet, Ferenczy Alex, Rohan Thomas, Chevarie-Davis Myriam, Louvanto Karolina, Tota Joseph, Shaw Eileen, Ramanakumar Agnihotram, Duarte Eliane, Kulaga Sophie, Robitaille Juliette, Franco Eduardo,
Affiliation:
1. Division of Cancer Epidemiology, Gerald Bronfman Department of Oncology, McGill University , Montréal , Canada 2. Département de Médecine Sociale et Préventive, Université de Montréal , Montréal , Canada 3. Centre de Recherche, Centre Hospitalier Universitaire de Sainte-Justine , Montréal , Canada 4. Center for Translational Research in Oncology, Instituto do Cancer do Estado de Sao Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo , São Paulo , Brazil 5. Department of Radiology and Oncology, Faculdade de Medicina, Universidade de São Paulo , São Paulo , Brazil
Abstract
Abstract
Background
We assessed the incidence and risk factors for first detection and redetection with the same human papillomavirus (HPV) genotype, and prevalence of cytological lesions during HPV redetections.
Methods
The Ludwig-McGill cohort study followed women aged 18–60 years from São Paulo, Brazil in 1993–1997 for up to 10 years. Women provided cervical samples for cytology testing and HPV DNA testing at each visit. A redetection was defined as a recurring genotype-specific HPV positive result after 1 or more intervening negative visits. Predictors of genotype-specific redetection were assessed using adjusted hazard ratios (aHR) with Cox regression modeling.
Results
In total, 2184 women contributed 2368 incident HPV genotype-specific first detections and 308 genotype-specific redetections over a median follow-up of 6.5 years. The cumulative incidence of redetection with the same genotype was 6.6% at 1 year and 14.8% at 5 years after the loss of positivity of the first detection. Neither age (aHR 0.90; 95% confidence interval [CI], .54–1.47 for ≥45 years vs < 25 years) nor new sexual partner acquisition (aHR 0.98; 95% CI, .70–1.35) were statistically associated with genotype-specific redetection. High-grade squamous intraepithelial lesion prevalence was similar during first HPV detections (2.9%) and redetection (3.2%).
Conclusions
Our findings suggest many HPV redetections were likely reactivations of latent recurring infections.
Funder
Ludwig Institute for Cancer Research US National Cancer Institute Canadian Institutes of Health Research Fonds de la Recherche du Québec en Santé
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Immunology and Allergy
Cited by
2 articles.
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