Functional Characterization of Plasmodium falciparum Surface-Related Antigen as a Potential Blood-Stage Vaccine Target-Reference-Cited by-同舟云学术

Functional Characterization of Plasmodium falciparum Surface-Related Antigen as a Potential Blood-Stage Vaccine Target

Published:2018-04-18 Issue:5 Volume:218 Page:778-790
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Amlabu Emmanuel¹²,Mensah-Brown Henrietta¹,Nyarko Prince B¹,Akuh Ojo-ajogu¹,Opoku Grace¹,Ilani Philip¹,Oyagbenro Richard¹,Asiedu Kwame¹,Aniweh Yaw¹,Awandare Gordon A¹^ORCID

Affiliation:

1. West African Center for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Legon, Accra

2. Department of Biochemistry, Kogi State University, Anyigba, Nigeria

Abstract

We have identified and functionally characterized a novel Plasmodium falciparum surface-related antigen (PfSRA) as a potential multistage vaccine candidate. The antigen is localized on both merozoites and gametocytes with high anti-PfSRA growth inhibition assay activity in laboratory strains and clinical isolates.

Funder

World Bank African Centres of Excellence

Developing Excellence in Leadership Training and Science (DELTAS) Africa

Wellcome Trust

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/article-pdf/218/5/778/25206966/jiy222.pdf

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