Assessment of Humoral Immune Responses to Repeated Influenza Vaccination in a Multiyear Cohort: A 5-Year Follow-up-Reference-Cited by-全球学者库

Assessment of Humoral Immune Responses to Repeated Influenza Vaccination in a Multiyear Cohort: A 5-Year Follow-up

Published:2023-08-25 Issue: Volume: Page:
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Sung Meng-Hsuan¹^ORCID,Billings W Zane¹,Carlock Michael A²³⁴⁵,Hanley Hannah B²,Bahl Justin¹²³⁶⁷,Handel Andreas¹⁷^ORCID,Ross Ted M²³⁴⁵,Shen Ye¹^ORCID

Affiliation:

1. Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia , Athens, Georgia , United States

2. Center for Vaccines and Immunology, University of Georgia , Athens, Georgia , United States

3. Department of Infectious Diseases, University of Georgia , Athens, Georgia , United States

4. Florida Research and Innovation Center, Cleveland Clinic , Port Saint Lucie, Florida , United States

5. Department of Infection Biology, Lehner Research Institute , Cleveland Clinic, Cleveland, Ohio , United States

6. Institute of Bioinformatics, University of Georgia , Athens, Georgia , United States

7. Center for the Ecology of Infectious Diseases, University of Georgia , Athens, Georgia , United States

Abstract

Abstract The long-term effects of host factors on vaccine-elicited immune responses have not been well studied, and the interactions of host factors with annual influenza vaccinations are yet to be explored. We analyzed data from a cohort of 386 individuals who received the standard-dose influenza vaccine and enrolled in ≥2 seasons from 2016 to 2020. Our analyses indicated disparate vaccine-elicited immune responses between males and females in adults when they were repeatedly vaccinated for at least 2 seasons. Notably, we found interactive effects between age and body mass index (BMI) on overall immune responses, and between sex at birth and BMI in adults.

Funder

University of Georgia Research Foundation

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Department of Health and Human Services

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiad319/51532783/jiad319.pdf

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