Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019-Reference-Cited by-全球学者库

Interferon-Induced Transmembrane Protein 3 Genetic Variant rs12252-C Associated With Disease Severity in Coronavirus Disease 2019

Published:2020-04-29 Issue:1 Volume:222 Page:34-37
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Zhang Yonghong¹²,Qin Ling¹,Zhao Yan¹,Zhang Ping²³,Xu Bin¹,Li Kang¹,Liang Lianchun¹,Zhang Chi¹,Dai Yanchao¹,Feng Yingmei¹,Sun Jianping¹,Hu Zhongjie¹,Xiang Haiping¹,Knight Julian C²³,Dong Tao²⁴,Jin Ronghua¹

Affiliation:

1. Beijing Youan Hospital, Capital Medical University, Beijing, People’s Republic of China

2. Chinese Academy of Medical Science Oxford Institute, University of Oxford, Oxford, United Kingdom

3. Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

4. MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom

Abstract

Abstract A major unanswered question in the current global coronavirus disease 2019 (COVID-19) outbreak is why severe disease develops in a small minority of infected individuals. In the current article, we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age-dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at-risk individuals.

Funder

Natural Science Foundation of Beijing Municipality

Beijing Municipal Science and Technology Commission

Beijing Municipal Administration of Hospitals

National Key Research and Development Project

Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences

Medical Research Council

Wellcome Trust

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy