Variant-Specific IgA Protects Against Omicron Infection-Reference-Cited by-同舟云学术

Variant-Specific IgA Protects Against Omicron Infection

Published:2023-11-23 Issue: Volume: Page:
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Goh Yun Shan¹,Fong Siew-Wai¹,Hor Pei Xiang¹,Loh Chiew Yee¹,Wang Bei²,Salleh Siti Nazihah Mohd²,Ngoh Eve Zi Xian²,Lee Raphael Tze Chuen³⁴,Poh Xuan Ying⁵^ORCID,Rao Suma⁵⁶,Chia Po Ying⁵⁶⁷,Ong Sean W X⁵⁶,Lee Tau Hong⁵⁶,Lim Clarissa⁵,Teo Jefanie⁵,Pada Surinder⁸,Sun Louisa Jin⁹,Ong Desmond Luan Seng¹⁰,Somani Jyoti¹¹,Lee Eng Sing⁷¹²,Maurer-Stroh Sebastian¹³⁴¹³¹⁴¹⁵^ORCID,Wang Cheng-I²,Leo Yee-Sin⁵⁶⁷¹⁶¹⁷,Lye David C⁵⁶⁷¹⁵^ORCID,Young Barnaby Edward⁵⁶⁷,Ng Lisa F P¹¹⁸¹⁹,Renia Laurent¹⁷²⁰^ORCID,Yu Jocelyn Jin,Soh Zheng Kuang,Chin Yi Qing,Lim Jonathan Jordon,Ongko Juwinda,Libau Eshele Anak,Theo Celine,Abdullah Mohammed Ridzwan Bin,Diong Shiau Hui,Yeo He Ping,Rouers Angeline,Wei Chang Zi,Tay Matthew Zirui,Torres-Ruesta Anthony,Wong Nathan,Huang Yuling,Ong Alice Soh Meoy,Chua Adeline Chiew Yen,Nguee Samantha,Tan Yong Jie,Neo Vanessa,Kam Isaac Kai Jie,Yadunandan Ajayanandan,Selvam Sooriya Kannan,Goh Jarvis,Ying Ng Kah,Yi Sim Xin,Lun Wong Wei,Loo Anna Xinyi,Loo Liang Hui, ,

Affiliation:

1. A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research , Singapore , Singapore

2. Singapore Immunology Network, Agency for Science, Technology and Research , Singapore , Singapore

3. Bioinformatics Institute, Agency for Science, Technology and Research , Singapore , Singapore

4. GISAID Global Data Science Initiative , Munich , Germany

5. National Centre for Infectious Diseases , Singapore , Singapore

6. Department of Infectious Diseases, Tan Tock Seng Hospital , Singapore , Singapore

7. Lee Kong Chian School of Medicine, Nanyang Technological University , Singapore , Singapore

8. Division of Infectious Diseases, Ng Teng Fong General Hospital , Singapore , Singapore

9. Infectious Diseases, Alexandra Hospital , Singapore , Singapore

10. National University Polyclinic , Singapore , Singapore

11. Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System , Singapore , Singapore

12. National Healthcare Group Polyclinics , Singapore , Singapore

13. National Public Health Laboratory , Singapore , Singapore

14. Department of Biological Sciences, National University of Singapore , Singapore , Singapore

15. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore , Singapore , Singapore

16. Saw Swee Hock School of Public Health, National University of Singapore , Singapore , Singapore

17. Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore , Singapore , Singapore

18. Health Protection Research Unit in Emerging and Zoonotic Infections, National Institute of Health Research, University of Liverpool , Liverpool , United Kingdom

19. Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool , Liverpool , United Kingdom

20. School of Biological Sciences, Nanyang Technological University , Singapore , Singapore

Abstract

Abstract Background The emergence of rapidly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, coupled with waning vaccine-induced immunity, has contributed to the rise of vaccine breakthrough infections. It is crucial to understand how vaccine-induced protection is mediated. Methods We examined 2 prospective cohorts of mRNA vaccinated and boosted individuals during the Omicron wave of infection in Singapore. Results We found that individuals who remain uninfected over the follow-up period had a higher variant-specific IgA, but not IgG, antibody response at 1 month after booster vaccination, compared with individuals who became infected. Conclusions We conclude that IgA may have a potential contributory role in protection against Omicron infection. Clinical Trials Registration . NCT05142319.

Funder

Biomedical Research

Council

Agency for Science, Technology and Research

National Medical Research Council

Singapore

US Food and Drug Administration

A*STAR

TF IPC, Ltd

Nanyang Technological University

Publisher

Oxford University Press (OUP)