Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

Author:

Takala-Harrison Shannon1,Jacob Christopher G.1,Arze Cesar2,Cummings Michael P.3,Silva Joana C.2,Dondorp Arjen M.4,Fukuda Mark M.5,Hien Tran Tinh6,Mayxay Mayfong789,Noedl Harald10,Nosten Francois49,Kyaw Myat P.11,Nhien Nguyen Thanh Thuy6,Imwong Mallika12,Bethell Delia5,Se Youry13,Lon Chanthap13,Tyner Stuart D.5,Saunders David L.5,Ariey Frederic14,Mercereau-Puijalon Odile15,Menard Didier16,Newton Paul N.79,Khanthavong Maniphone17,Hongvanthong Bouasy17,Starzengruber Peter10,Fuehrer Hans-Peter10,Swoboda Paul10,Khan Wasif A.18,Phyo Aung Pyae41920,Nyunt Myaing M.1,Nyunt Myat H.11,Brown Tyler S.1,Adams Matthew1,Pepin Christopher S.1,Bailey Jason1,Tan John C.21,Ferdig Michael T.22,Clark Taane G.2324,Miotto Olivo42526,MacInnis Bronwyn26,Kwiatkowski Dominic P.2526,White Nicholas J.4,Ringwald Pascal27,Plowe Christopher V.1

Affiliation:

1. Howard Hughes Medical Institute/Center for Vaccine Development

2. Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore

3. Center for Bioinformatics and Computational Biology, University of Maryland, College Park

4. Mahidol-Oxford Tropical Medicine Research Unit

5. Armed Forces Research Institute of Medical Sciences, Bangkok

6. Center for Tropical Medicine, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam

7. Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital

8. Faculty of Postgraduate Studies, University of Health Sciences

9. Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford

10. Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Austria

11. Department of Medical Research (Lower Myanmar), Yangon

12. Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University

13. Armed Forces Research Institute of Medical Sciences

14. GGIV Unit, Parasitology and Mycology Departement

15. Parasite Molecular Immunology Unit, Institut Pasteur, Paris, France

16. Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia

17. Center of Malariology, Parasitology, and Entomology, Vientiane, Laos

18. International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

19. Shoklo Malaria Research Unit

20. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand

21. Research and Development, Roche NimbleGen, Madison, Wisconsin

22. Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Indiana

23. Faculty of Epidemiology and Population Health

24. Faculty Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine

25. MRC Centre for Genomics and Global Health, Oxford University and Wellcome Trust Sanger Institute

26. Malaria Programme, Wellcome Trust Sanger Institute, Hinxton, United Kingdom

27. Drug Resistance and Containment Unit, Global Malaria Programme, World Health Organization, Geneva, Switzerland

Funder

the National Institute of Allergy and Infectious Diseases National Institutes of Health

the World Health Organization Global Malaria Programme, the Doris Duke Charitable Foundation, and the Howard Hughes Medical Institute, for genomic analyses the Wellcome Trust Sanger Institute

the Wellcome Trust Centre for Human Genetics

the Resource Centre for Genomic Epidemiology of Malaria

Wellcome Trust Mahidol University Oxford Tropical Medicine Research Programme, through core funding from the Wellcome Trust Centre for Genomics and Global Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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