Time Scales of Human Mpox Transmission in The Netherlands

Author:

Miura Fuminari12ORCID,Backer Jantien A1,van Rijckevorsel Gini13,Bavalia Roisin3,Raven Stijn14,Petrignani Mariska5,Ainslie Kylie E C16,Wallinga Jacco17,van Benthem Birgit,Brandwagt Diederik,Bos Hanna,van Bokhoven-Rombouts Colette,Bovée Lian,Rovers Chantal P,van Cleef Brigitte,van Dam Alje P.,van Dael Rik,van der Eijk Annemiek A.,Ellerbroek Pauline,van Ewijk Catharina,Franz Eelco,GeurtsvanKessel Corine,van der Giessen Joke,Götz Hannelore,Häger Josette M W,van den Hof Susan,Hoornenborg Elske,Hintaran Putri,de Jonge Jorgen,Joosten Rosa,Koopmans Marion,Kosterman Kevin,Lange Jente,Leenstra Tjalling,Ooms Daisy,Oorsprong Danielle,Op de Coul Eline,Reurings Demi,van Rijckevorsel Gini,Sips Gregorius J,de Stoppelaar Sacha F,Vollaard Albert,Voordouw Bettie,Vennema Harry,de Vries Henry J C,Ellen Veldkamp Karin,Weijdema Klaartje,Westerhuis Geert,te Wierik Margreet J M,Welkers Matthijs R A,Waegemaekers Toos,Wallinga Jacco,Zantkuijl Paul,

Affiliation:

1. Centre for Infectious Disease Control, National Institute for Public Health and the Environment , Bilthoven , The Netherlands

2. Center for Marine Environmental Studies, Ehime University , Ehime , Japan

3. Department of Infectious Diseases, Public Health Service Amsterdam

4. Department of Infectious Diseases, Public Health Service Region Utrecht , Zeist

5. Department of Infectious Diseases, Public Health Service Haaglanden , Den Haag , The Netherlands

6. School of Public Health, The University of Hong Kong , Hong Kong Special Administrative Region , China

7. Department of Biomedical Data Sciences, Leiden University Medical Center , The Netherlands

Abstract

Abstract Mpox has spread rapidly to many countries in nonendemic regions. After reviewing detailed exposure histories of 109 pairs of mpox cases in the Netherlands, we identified 34 pairs where transmission was likely and the infectee reported a single potential infector with a mean serial interval of 10.1 days (95% credible interval, 6.6–14.7 days). Further investigation into pairs from 1 regional public health service revealed that presymptomatic transmission may have occurred in 5 of 18 pairs. These findings emphasize that precaution remains key, regardless of the presence of recognizable symptoms of mpox.

Funder

Netherlands Ministry of Health

Welfare and Sport

Japan Society for the Promotion of Science

JSPS KAKENHI

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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