Drug Concentrations in Hair and Dried Blood Spots as Preexposure Prophylaxis Adherence Metrics During Pregnancy and Postpartum-Reference-Cited by-同舟云学术

Drug Concentrations in Hair and Dried Blood Spots as Preexposure Prophylaxis Adherence Metrics During Pregnancy and Postpartum

Published:2024-05-03 Issue: Volume: Page:
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Wu Linxuan¹²,Kinuthia John²³,Anderson Peter L⁴,Baeten Jared M¹²⁵,Dettinger Julia C²,Gandhi Monica⁶^ORCID,Gomez Laurén¹²,John-Stewart Grace¹²⁵⁷^ORCID,Marwa Mary M³,Ngumbau Nancy³,Otieno Felix³,Omondi Pascal³,Odhiambo Ben³,Watoyi Salphine³,Pintye Jillian²⁸^ORCID

Affiliation:

1. Department of Epidemiology, University of Washington , Seattle

2. Department of Global Health, University of Washington , Seattle

3. Department of Research and Programs, Kenyatta National Hospital , Nairobi , Kenya

4. Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado , Aurora

5. Department of Medicine, University of Washington , Seattle

6. Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco

7. Department of Pediatrics, School of Medicine, University of Washington , Seattle

8. Department of Biobehavioral Nursing and Health Informatics, School of Nursing, University of Washington , Seattle

Abstract

Abstract We evaluated hair tenofovir (TFV) concentrations as an adherence metric for HIV preexposure prophylaxis during pregnancy and postpartum and compared hair levels with TFV-diphosphate levels in dried blood spots (DBSs). Overall 152 hair samples from 102 women and 36 hair-DBS paired samples from 29 women were collected from a subset of women in a cluster-randomized trial. Having a partner with HIV was associated with higher hair TFV levels (P < .001). Hair TFV concentrations were strongly correlated with DBS TFV-diphosphate levels (r = 0.76, P < .001), indicating hair as a promising cumulative adherence metric for perinatal preexposure prophylaxis assessment.

Funder

National Institute of Allergy and Infectious Diseases

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Institutes of Health

NICHD

National Institute of Nursing Research

University of Washington's Center for AIDS Research Behavioral Sciences Core and Biometrics Core

Global Center for the Integrated Health of Women, Adolescents, and Children

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiae208/57677795/jiae208.pdf

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