Slow Waning of Antibodies Following BNT162b2 as a Third Dose in Adults Who Had Previously Received 2 Doses of Inactivated Vaccine-Reference-Cited by-全球学者库

Slow Waning of Antibodies Following BNT162b2 as a Third Dose in Adults Who Had Previously Received 2 Doses of Inactivated Vaccine

Published:2022-09-15 Issue:2 Volume:227 Page:251-255
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Cowling Benjamin J¹²^ORCID,Cheng Samuel M S¹,Martín-Sánchez Mario¹,Au Niki Y M¹,Chan Karl C K¹,Li John K C¹,Fung Lison W C¹,Luk Leo L H¹,Tsang Leo C H¹,Ip Dennis K M¹,Poon Leo L M¹³⁴,Leung Gabriel M¹²,Peiris J S Malik¹³⁴,Leung Nancy H L¹²

Affiliation:

1. World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong , Pokfulam, Hong Kong Special Administrative Region , China

2. Laboratory of Data Discovery for Health, Hong Kong Science and Technology Park , New Territories, Hong Kong Special Administrative Region , China

3. University of Hong Kong–Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong , Pokfulam, Hong Kong Special Administrative Region , China

4. Centre for Immunology and Infection, Hong Kong Science and Technology Park , New Territories, Hong Kong Special Administrative Region , China

Abstract

Abstract We administered BNT162b2 as a third dose to 314 adults aged ≥30 years who had previously received 2 doses of inactivated vaccine. We collected blood samples before the third dose and again after 1 month and 6 months, and found robust antibody responses to the ancestral strain at 6 months after receipt of BNT162b2. Antibody responses to Omicron BA.2 by live virus neutralization were weaker after the third dose and had declined to a low level by 6 months.

Funder

Research Grants Council of the Hong Kong Special Administrative Region, China

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiac380/46168068/jiac380.pdf

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