Modelling intensive care unit capacity under different epidemiological scenarios of the COVID-19 pandemic in three Western European countries

Author:

McCabe Ruth123ORCID,Kont Mara D1ORCID,Schmit Nora1ORCID,Whittaker Charles1ORCID,Løchen Alessandra1ORCID,Baguelin Marc1ORCID,Knock Edward1ORCID,Whittles Lilith K145ORCID,Lees John1ORCID,Brazeau Nicholas F1ORCID,Walker Patrick GT1ORCID,Ghani Azra C1ORCID,Ferguson Neil M14ORCID,White Peter J145ORCID,Donnelly Christl A1234ORCID,Hauck Katharina14ORCID,Watson Oliver J1ORCID

Affiliation:

1. MRC Centre for Global Infectious Disease Analysis & WHO Collaborating Centre for Infectious Disease Modelling, Abdul Latif Jameel Institute for Disease and Emergency Analytics, Imperial College London, St Mary’s Campus, Norfolk Place, London, UK

2. Department of Statistics, University of Oxford, Oxford, UK

3. NIHR Health Research Protection Unit in Emerging and Zoonotic Diseases, The Ronald Ross Building, University of Liverpool, Liverpool, UK

4. NIHR Health Research Protection Unit in Modelling and Health Economics, Imperial College London, St Mary’s Campus, Norfolk Place, London, UK

5. Modelling and Economics Unit, National Infection Service, Public Health England, London, UK

Abstract

Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has placed enormous strain on intensive care units (ICUs) in Europe. Ensuring access to care, irrespective of COVID-19 status, in winter 2020–2021 is essential. Methods An integrated model of hospital capacity planning and epidemiological projections of COVID-19 patients is used to estimate the demand for and resultant spare capacity of ICU beds, staff and ventilators under different epidemic scenarios in France, Germany and Italy across the 2020–2021 winter period. The effect of implementing lockdowns triggered by different numbers of COVID-19 patients in ICUs under varying levels of effectiveness is examined, using a ‘dual-demand’ (COVID-19 and non-COVID-19) patient model. Results Without sufficient mitigation, we estimate that COVID-19 ICU patient numbers will exceed those seen in the first peak, resulting in substantial capacity deficits, with beds being consistently found to be the most constrained resource. Reactive lockdowns could lead to large improvements in ICU capacity during the winter season, with pressure being most effectively alleviated when lockdown is triggered early and sustained under a higher level of suppression. The success of such interventions also depends on baseline bed numbers and average non-COVID-19 patient occupancy. Conclusion Reductions in capacity deficits under different scenarios must be weighed against the feasibility and drawbacks of further lockdowns. Careful, continuous decision-making by national policymakers will be required across the winter period 2020–2021.

Funder

MRC Centre for Global Infectious Disease Analysis

UK Medical Research Council (MRC) and the UK Foreign, Commonwealth & Development Office

MRC/FCDO Concordat

EDCTP2 programme supported by the European Union

Imperial College Medical Research Council Doctoral Training Partnership

National Institute for Health Research (NIHR) HPRU in Modelling and Health Economics

Public Health England

Imperial College London and LSHTM

NIHR HPRU in Emerging and Zoonotic Infections

University of Oxford

University of Liverpool and Liverpool School of Tropical Medicine

Wellcome Trust and FCDO

Publisher

Oxford University Press (OUP)

Subject

General Medicine,Epidemiology

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