Proposal of recommended experimental protocols for <i>in vitro</i> and <i>in vivo</i> evaluation methods of boron agents for neutron capture therapy-Reference-Cited by-同舟云学术

Proposal of recommended experimental protocols for in vitro and in vivo evaluation methods of boron agents for neutron capture therapy

Published:2023-09-16 Issue:6 Volume:64 Page:859-869
ISSN:0449-3060
Container-title:Journal of Radiation Research
language:en
Short-container-title:

Author:

Hattori Yoshihide¹,Andoh Tooru²,Kawabata Shinji³,Hu Naonori⁴⁵,Michiue Hiroyuki⁶,Nakamura Hiroyuki⁷,Nomoto Takahiro⁸⁹,Suzuki Minoru⁵,Takata Takushi⁵,Tanaka Hiroki⁵,Watanabe Tsubasa⁵,Ono Koji⁴

Affiliation:

1. Research Center for BNCT, Osaka Metropolitan University , 1-1 Gakuen-cho, Nakaku, Sakai 599-8531 , Japan

2. Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Kobe Gakuin University , Kobe 650-8586 , Japan

3. Department of Neurosurgery, Osaka Medical and Pharmaceutical University , 2-7 Daigaku-machi, Takatsuki-shi, Osaka 569-8686 , Japan

4. Kansai BNCT Medical Center, Osaka Medical and Pharmaceutical University , 2-7 Daigaku-machi, Takatsuki-shi, Osaka 569-8686 , Japan

5. Institute for Integrated Radiation and Nuclear Science, Kyoto University , 2, Asashiro-Nishi, Kumatori-cho, Sennan-gun 590-0494 Japan

6. Neutron Therapy Research Center, Okayama University , 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558 , Japan

7. Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology , 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8503 , Japan

8. Department of Life Sciences , Graduate School of Arts and Sciences, , 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902 , Japan

9. The University of Tokyo , Graduate School of Arts and Sciences, , 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902 , Japan

Abstract

Abstract Recently, boron neutron capture therapy (BNCT) has been attracting attention as a minimally invasive cancer treatment. In 2020, the accelerator-based BNCT with L-BPA (Borofalan) as its D-sorbitol complex (Steboronine®) for head and neck cancers was approved by Pharmaceutical and Medical Devices Agency for the first time in the world. As accelerator-based neutron generation techniques are being developed in various countries, the development of novel tumor-selective boron agents is becoming increasingly important and desired. The Japanese Society of Neutron Capture Therapy believes it is necessary to propose standard evaluation protocols at each stage in the development of boron agents for BNCT. This review summarizes recommended experimental protocols for in vitro and in vivo evaluation methods of boron agents for BNCT based on our experience with L-BPA approval.

Funder

Osaka Metropolitan University

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Radiology, Nuclear Medicine and imaging,Radiation

Link

https://academic.oup.com/jrr/article-pdf/64/6/859/53652300/rrad064.pdf

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