Human Metapneumovirus-Associated Hospitalization in HIV-1 Exposed Uninfected and HIV-1 Uninfected Children Less Than 5 Years in South Africa

Author:

Ramocha Lesego M12,Dorfman Jeffrey R123ORCID,Groome Michelle124,Baillie Vicky12,Verwey Charl15,Laubscher Marius12,Nunes Marta C12,Madhi Shabir A124

Affiliation:

1. South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg , South Africa

2. Department of Science/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, Faculty of Health Sciences , Johannesburg , South Africa

3. Division of Medical Virology, Department of Pathology, Stellenbosch University , Cape Town , South Africa

4. African Leadership in Vaccinology Expertise (ALIVE), Faculty of Health Sciences, University of the Witwatersrand , Johannesburg , South Africa

5. Department of Pediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg , South Africa

Abstract

Abstract Using hospital surveillance data, we estimated Human metapneumovirus (hMPV) hospitalization incidence by age and HIV-exposure status. hMPV-associated hospitalization incidence was highest in <1-year children. Incidence rate ratios of HIV-exposed over unexposed children were 1.5 (95%CI 0.9–2.4) for <6-month children, 1.4 (95%CI 0.7–2.4) for 6- to 11-month children and 0.9 (95%CI 0.4–1.9) for 12- to 59-month children.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine,Pediatrics, Perinatology and Child Health

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