Effect of different forms of selenium in osteoporosis rat model induced by retinoic acid

Abstract

AbstractOsteoporosis is a typical physiological disease, the main symptoms of which are brittle fracture, bone pain and easily deformed. As an individual ages, the prevalence of osteoporosis increases year by year. In the present study, selenium with antioxidant, immunomodulatory and anti-tumor effects was used to prevent osteoporosis induced by retinoic acid. The serum calcium contents in the selenium-treated groups (sodium selenite and selenomethionine) were significantly higher (P<0.05) than those in the model group in both the prevention and treatment studies. After prevention, glutamic-oxalacetic transaminase transaminase (GOT), glutamate transaminase (GPT), alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRACP) levels were significantly (P<0.05) decreased. In the treatment study, the serum calcium and phosphorus contents of the rats increased after selenium treatment. There was no significant change (P>0.05) in the activity of GOT and GPT. The content of ALP decreased obviously and the TRACP enzyme activity increased. Overall, these results showed that different forms of selenium compounds have great potential in preventing and treating osteoporosis.