Allelic reprogramming of chromatin states in human early embryos-Reference-Cited by-全球学者库

Allelic reprogramming of chromatin states in human early embryos

Published:2024-01-02 Issue: Volume: Page:
ISSN:2095-5138
Container-title:National Science Review
language:en
Short-container-title:

Author:

Yuan Shenli¹²³⁴,Gao Lei²,Tao Wenrong¹⁵,Zhan Jianhong²³,Lu Gang⁴,Zhang Jingye¹⁵,Zhang Chuanxin¹⁵,Yi Lizhi²,Liu Zhenbo²,Hou Zhenzhen¹⁵,Dai Min³^ORCID,Zhao Han¹⁵^ORCID,Chen Zi-Jiang¹⁵⁶^ORCID,Liu Jiang²³⁷,Wu Keliang¹⁵

Affiliation:

1. Center for Reproductive Medicine, Shandong University , Jinan 250012 , China

2. CAS Key Laboratory of Genome Sciences and Information, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, and China National Center for Bioinformation, Chinese Academy of Sciences , Beijing 100101 , China

3. University of Chinese Academy of Sciences , Beijing 100049 , China

4. CUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, the Chinese University of Hong Kong , Hong Kong , China

5. Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan 250012 , China

6. Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200135 , China

7. CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences , Kunming 650223 , China

Abstract

Abstract The reprogramming of parental epigenomes in human early embryo remains elusive. To what extent the characteristics of parental epigenomes are conserved between human and mouse are currently unknown. Here, we mapped parental haploid epigenomes using human parthenogenetic (PG) and androgenetic (AG) embryos. Human embryos have a larger portion of genome with parentally specific epigenetic states than mouse embryos. The allelic patterns of epigenetic states for orthologous regions are not conserved between human and mouse. Nevertheless, it is conserved that maternal DNA methylation and paternal H3K27me3 are associated with the repression of two alleles in human and mouse. In addition, for DNA methylation dependent imprinting, we report 19 novel imprinted genes and their associated germline differentially methylated regions (gDMRs). Unlike mouse, H3K27me3-dependent imprinting is not observed in human early embryo. Collectively, allele-specific epigenomic reprogramming is different between human and mouse.

Publisher

Oxford University Press (OUP)

Subject

Multidisciplinary

Link

https://academic.oup.com/nsr/advance-article-pdf/doi/10.1093/nsr/nwad328/54942871/nwad328.pdf