Loci influencing blood pressure identified using a cardiovascular gene-centric array

Author:

Ganesh Santhi K.1,Tragante Vinicius23,Guo Wei4,Guo Yiran5,Lanktree Matthew B.6,Smith Erin N.7,Johnson Toby89,Castillo Berta Almoguera5,Barnard John10,Baumert Jens11,Chang Yen-Pei Christy1213,Elbers Clara C.314,Farrall Martin15,Fischer Mary E.16,Franceschini Nora17,Gaunt Tom R.18,Gho Johannes M.I.H.2,Gieger Christian19,Gong Yan20,Isaacs Aaron21,Kleber Marcus E.2223,Leach Irene Mateo24,McDonough Caitrin W.20,Meijs Matthijs F.L.2,Mellander Olle2526,Molony Cliona M.27,Nolte Ilja M.28,Padmanabhan Sandosh29,Price Tom S.30,Rajagopalan Ramakrishnan31,Shaffer Jonathan32,Shah Sonia33,Shen Haiqing12,Soranzo Nicole34,van der Most Peter J.28,Van Iperen Erik P.A.3536,Van Setten Jessic A.3,Vonk Judith M.28,Zhang Li10,Beitelshees Amber L.10,Berenson Gerald S.37,Bhatt Deepak L.38,Boer Jolanda M.A.39,Boerwinkle Eric40,Burkley Ben20,Burt Amber31,Chakravarti Aravinda41,Chen Wei37,Cooper-DeHoff Rhonda M.20,Curtis Sean P.42,Dreisbach Albert12,Duggan David43,Ehret Georg B.41,Fabsitz Richard R.44,Fornage Myriam40,Fox Ervin12,Furlong Clement E.31,Gansevoort Ron T.45,Hofker Marten H.46,Hovingh G. Kees47,Kirkland Susan A.48,Kottke-Marchant Kandice49,Kutlar Abdullah50,LaCroix Andrea Z.51,Langaee Taimour Y.20,Li Yun R.5,Lin Honghuang52,Liu Kiang53,Maiwald Steffi54,Malik Rainer5556,Murugesan Gurunathan49,Newton-Cheh Christopher5758,O'Connell Jeffery R.13,Onland-Moret N. Charlotte314,Ouwehand Willem H.59,Palmas Walter32,Penninx Brenda W.60,Pepine Carl J.61,Pettinger Mary44,Polak Joseph F.62,Ramachandran Vasan S.5263,Ranchalis Jane31,Redline Susan64,Ridker Paul M.64,Rose Lynda M.64,Scharnag Hubert165,Schork Nicholas J.66,Shimbo Daichi32,Shuldiner Alan R.1367,Srinivasan Sathanur R.37,Stolk Ronald P.28,Taylor Herman A.12,Thorand Barbara11,Trip Mieke D.68,van Duijn Cornelia M.21,Verschuren W. Monique39,Wijmenga Cisca69,Winkelmann Bernhard R.70,Wyatt Sharon71,Young J. Hunter72,Boehm Bernhard O.73,Caulfield Mark J.8,Chasman Daniel I.64,Davidson Karina W.74,Doevendans Pieter A.2,FitzGerald Garret A.75,Gums John G.76,Hakonarson Hakon5,Hillege Hans L.24,Illig Thomas7778,Jarvik Gail P.31,Johnson Julie A.20,Kastelein John J.P.47,Koenig Wolfgang79,März Winfried2380,Mitchell Braxton D.13,Murray Sarah S.81,Oldehinkel Albertine J.82,Rader Daniel J.83,Reilly Muredach P.83,Reiner Alex P.51,Schadt Eric E.84,Silverstein Roy L.8586,Snieder Harold28,Stanton Alice V.87,Uitterlinden André G.88,van der Harst Pim24,van der Schouw Yvonne T.14,Samani Nilesh J.8990,Johnson Andrew D.63,Munroe Patricia B.89,de Bakker Paul I.W.3145791,Zhu Xiaofeng4,Levy Daniel92,Keating Brendan J.5,Asselbergs Folkert W.231435, ,

Affiliation:

1. Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, MI, USA,

2. Department of Cardiology, Division Heart and Lungs,

3. Department of Medical Genetics and

4. Department of Epidemiology and Biostatistics, School of Medicine and

5. Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA,

6. Departments of Medicine and Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada,

7. Department of Pediatrics and Rady's Children's Hospital, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA,

8. Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and

9. The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK,

10. Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA,

11. Institute of Epidemiology II,

12. Department of Medicine and

13. Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA,

14. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands,

15. Department of Cardiovascular Medicine, The Wellcome Trust Centre for Human Genetics, University of Oxford, OxfordOX3 7BN, UK,

16. Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA,

17. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA,

18. MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK,

19. Institute of Genetic Epidemiology and

20. Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and

21. Genetic Epidemiology Unit, Department of Epidemiology and

22. LURIC Study nonprofit LLC, Freiburg, Germany,

23. Mannheim Institute of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany,

24. Department of Cardiology,

25. Hypertension and Cardiovascular Disease, Department of Clinical Sciences, Lund University, Malmö, Sweden,

26. Centre of Emergency Medicine, Skåne University Hospital, Malmö, Sweden,

27. Department of Genetics, Rosetta Inpharmatics, Seattle, WA, USA,

28. Department of Epidemiology,

29. BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK,

30. MRC SGDP Centre, Institute of Psychiatry, London, UK,

31. Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA,

32. Department of Medicine, Columbia University, New York, NY, USA,

33. UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, Kathleen Lonsdale Building, Gower Place, London WC1E 6BT, UK,

34. Human Genetics and

35. Durrer Center for Cardiogenetic Research,

36. Department of Clinical Epidemiology, Biostatistics and Bioinformatics,

37. Department of Epidemiology, Tulane University, 1440 Canal Street, Suite 1829, New Orleans, LA, USA,

38. VA Boston Healthcare System, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA,

39. National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands,

40. Human Genetics Center and Institute of Molecular Medicine and Division of Epidemiology, University of Texas Health Science Center, Houston, TX, USA,

41. Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine and

42. Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA,

43. Translational Genomics Research Institute, Phoenix, AZ, USA,

44. Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD, USA,

45. Division of Nephrology, Department of Medicine,

46. Molecular Genetics, Medical Biology Section, Department of Pathology and Medical Biology,

47. Department of Vascular Medicine and

48. Department of Community Health and Epidemiology, Dalhousie University, Canada,

49. Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA,

50. Medical College of Georgia, Augusta, GA, USA,

51. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA,

52. Department of Medicine, Boston University School of Medicine, Boston, MA, USA,

53. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA,

54. Department of Vascular Medicine, University of Amsterdam, Amsterdam, The Netherlands,

55. Institute for Stroke and Dementia Research and

56. Neurologische Klinik, Klinikum Grosshadern, Ludwig-Maximilians-Universität, München, Germany,

57. Broad Institute of Harvard and MIT, Cambridge, MA, USA,

58. Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA,

59. Department of Haematology, University of Cambridge and NHS Blood and Transplant, Cambridge and Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK,

60. Department of Psychiatry/EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands,

61. Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, FL, USA,

62. Department of Radiology, Tufts Medical Center,

63. National Heart, Lung and Blood Institute's Framingham Heart Study, 73 Mt.Wayte Avenue Suite #2, Framingham, MA, USA,

64. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School and

65. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria,

66. The Scripps Translational Science Institute and The Scripps Research Institute, 3344 N. Torrey Pines Ct. Ste 300, La Jolla, CA, USA,

67. Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, MD, USA,

68. Department of Cardiology, AMC, Amsterdam, The Netherlands,

69. Department of Genetics,

70. Cardiology Group, Frankfurt-Sachsenhausen,

71. School of Nursing, University of Mississippi Medical Center, Jackson, MS, USA,

72. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA,

73. Division of Endocrinology and

74. Departments of Medicine & Psychiatry, Columbia University, New York, NY, USA,

75. The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA,

76. Departments of Pharmacotherapy and Translational Research and Community Health and Family Medicine, University of Florida, Gainesville, FL, USA,

77. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany,

78. Hannover Unified Biobank, Hannover Medical School, Hannover, Germany,

79. Department of Internal Medicine I—Cardiology, University of Ulm Medical Centre, Ulm, Germany,

80. Synlab Academy, Mannheim, Germany,

81. Scripps Translational Science Institute and Scripps Health, 3344 N. Torrey Pines Ct. Ste 300, La Jolla, CA, USA,

82. Interdisciplinary Center Psychopathology and Emotion Regulation, Groningen University, University Medical Center Groningen, Groningen, The Netherlands,

83. Cardiovascular Institute, The Perelman School of Medicine at the University of Pennsylvania, PA, USA,

84. Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA,

85. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA,

86. Department of Cell Biology, Lerner Research Institute, Cleveland Clinic,

87. Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland,

88. Departments of Epidemiology and Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands,

89. Department of Cardiovascular Sciences, University of Leicester and

90. Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE3 9QP, UK

91. Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA,

92. Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA, USA,

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

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