AMPK activation by peri-sciatic nerve administration of ozone attenuates CCI-induced neuropathic pain in rats

Author:

Lu Lijuan12,Pan Cailong2,Chen Lu3,Hu Liang2,Wang Chaoyu2,Han Yuan2,Yang Yanjing4,Cheng Zhixiang5,Liu Wen-Tao2

Affiliation:

1. Department of Pain, Affiliated Drum Tower Hospital of Medical School of Nanjing University, Nanjing 210008, China

2. Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China

3. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China

4. Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029, China

5. Department of Pain Management & Cancer Biotherapy Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Funder

National Natural Science Foundation of China

Open Project Program of the State Key Laboratory of Natural Medicines

China Pharmaceutical University

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Genetics,Molecular Biology,General Medicine

Reference61 articles.

1. The A-type potassium channel Kv4.2 is a substrate for the mitogen-activated protein kinase ERK;Adams;J. Neurochem.,2000

2. Bisphosphonate-related osteonecrosis of the jaw (BRONJ): 5 year experience in the treatment of 131 cases with ozone therapy;Agrillo;Eur. Rev. Med. Pharmacol. Sci.,2012

3. Ozone as an adjunct to conventional nonsurgical therapy in chronic periodontitis: a randomized controlled clinical trial;Al Habashneh;J. Periodontal. Res.,2015

4. Mechanisms of disease: neuropathic pain—a clinical perspective;Baron;Nat. Clin. Pract. Neurol.,2006

5. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment;Baron;Lancet Neurol.,2010

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