HumanLectome, an update of UniLectin for the annotation and prediction of human lectins-Reference-Cited by-同舟云学术

HumanLectome, an update of UniLectin for the annotation and prediction of human lectins

Published:2023-10-27 Issue:D1 Volume:52 Page:D1683-D1693
ISSN:0305-1048
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Schnider Boris¹²,M’Rad Yacine¹²,el Ahmadie Jalaa¹²³,de Brevern Alexandre G⁴^ORCID,Imberty Anne³^ORCID,Lisacek Frederique¹²⁵^ORCID

Affiliation:

1. Proteome Informatics Group, SIB Swiss Institute of Bioinformatics , CH-1211 Geneva , Switzerland

2. Computer Science Department, University of Geneva , CH-1227 Geneva , Switzerland

3. University Grenoble Alpes , CNRS, CERMAV, F-38000 Grenoble , France

4. Université Paris Cité and Université de la Réunion and Université des Antilles , INSERM, BIGR, DSIMB Bioinformatics Team, F-75014 Paris , France

5. Section of Biology, University of Geneva , CH-1205 Geneva , Switzerland

Abstract

Abstract The UniLectin portal (https://unilectin.unige.ch/) was designed in 2019 with the goal of centralising curated and predicted data on carbohydrate-binding proteins known as lectins. UniLectin is also intended as a support for the study of lectomes (full lectin set) of organisms or tissues. The present update describes the inclusion of several new modules and details the latest (https://unilectin.unige.ch/humanLectome/), covering our knowledge of the human lectome and comprising 215 unevenly characterised lectins, particularly in terms of structural information. Each HumanLectome entry is protein-centric and compiles evidence of carbohydrate recognition domain(s), specificity, 3D-structure, tissue-based expression and related genomic data. Other recent improvements regarding interoperability and accessibility are outlined.

Funder

Université Grenoble Alpes

Glyco@Alps

Labex Arcane

Swiss Federal Government

State Secretariat for Education, Research and Innovation

Swiss Institute of Bioinformatics and hosted at the Vital-IT Competency Center

University of Geneva

Publisher

Oxford University Press (OUP)

Subject

Genetics