Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART: a multicohort European case–control study using centralized ultrasensitive 454 pyrosequencing

Author:

Cozzi-Lepri Alessandro1,Noguera-Julian Marc2,Di Giallonardo Francesca3,Schuurman Rob4,Däumer Martin5,Aitken Sue4,Ceccherini-Silberstein Francesca6,D'Arminio Monforte Antonella7,Geretti Anna Maria8,Booth Clare L.9,Kaiser Rolf10,Michalik Claudia1112,Jansen Klaus11,Masquelier Bernard13,Bellecave Pantxika13,Kouyos Roger D.3,Castro Erika14,Furrer Hansjakob15,Schultze Anna1,Günthard Huldrych F.3,Brun-Vezinet Francoise16,Paredes Roger2,Metzner Karin J.3,Paredes Roger,Metzner Karin J.,Cozzi-Lepri Alessandro,Schuurman Rob,Brun-Vezinet Francoise,Günthard Huldrych,Ceccherini-Silberstein Francesca,Kaiser Rolf,Geretti Anna Maria,Brockmeyer Norbert,Masquelier Bernard, ,

Affiliation:

1. University College London, London, UK

2. Institut de Recerca de la SIDA IrsiCaixa i Unitat VIH, Universitat Autònoma de Barcelona, Universitat de Vic, Catalonia, Spain

3. Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

4. Department of Virology, University Medical Centre, Utrecht, The Netherlands

5. Institut für Immunologie und Genetik, Kaiserslautern, Germany

6. Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy

7. Department of Health Sciences, Clinic of Infectious Diseases, ‘San Paolo’ Hospital, University of Milan, Milan, Italy

8. Institute of Infection & Global Health, University of Liverpool, Liverpool, UK

9. Department of Virology, Royal Free London NHS Foundation Trust, London, UK

10. Institute of Virology, University of Cologne, Cologne, Germany

11. Competence Network for HIV/AIDS, Bochum, Germany and Clinic for Dermatology, Venerology and Allergology of the Ruhr-Universität, Bochum, Germany

12. Clinical Trial Centre (ZKS), University of Cologne, Cologne, Germany

13. Laboratoire de Virologie, CHU de Bordeaux and MFP-UMR5234, Université Bordeaux 2, Bordeaux, France

14. Addiction Medicine, Service of Community Psychiatry, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

15. Department of Infectious Diseases, Bern University Hospital and University of Bern, Bern, Switzerland

16. Department of Virology, Bichat University Hospital, Paris, France

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Microbiology (medical)

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