Increased bioavailability of diosmetin-7-glucoside-γ-cyclodextrin inclusion complex compared with diosmin in Sprague-Dawley rats-Reference-Cited by-同舟云学术

Increased bioavailability of diosmetin-7-glucoside-γ-cyclodextrin inclusion complex compared with diosmin in Sprague-Dawley rats

Published:2023-05-03 Issue:7 Volume:87 Page:771-776
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Moriwaki Masamitsu¹,Kito Kento¹,Nakagawa Ryo¹,Kapoor Mahendra P¹,Matsumiya Yoshiki¹,Fukuhara Tomohisa¹,Kobayashi Junya¹,Satomoto Kensuke²,Yamagata Hiroshi²,Kuroiwa Yuichi²

Affiliation:

1. Nutrition Division, Taiyo Kagaku Co. Ltd. , Yokkaichi , Mie, Japan

2. Gotemba Laboratory, BoZo Research Center Inc. , Gotemba-shi, Shizuoka , Japan

Abstract

ABSTRACT Diosmin (DSN) is found mainly in citrus fruits, and has potent antioxidant effects. This study aimed to evaluate pharmacokinetics of diosmetin-7-glucoside-γ-cyclodextrin (DIOSG-CD) inclusion complex. The area under the curve values from AUC0-24 of DIOSG-CD, prepared by reacting DSN and naringinase with γ-CD, were approximately 800-fold higher than those of DSN following their administration in Sprague-Dawley rats.

Funder

Taiyo Kagaku Co. Ltd.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbad051/50320265/zbad051.pdf

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