Identification of aminobenzoic acids as selective inhibitors of the N-terminal phosphatase of soluble epoxide hydrolase-Reference-Cited by-同舟云学术

Identification of aminobenzoic acids as selective inhibitors of the N-terminal phosphatase of soluble epoxide hydrolase

Published:2023-02-09 Issue:5 Volume:87 Page:511-515
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Kihara Yasuhiro¹,Nishimura Erina¹,Kanai Chisato²,Kitano Yoshikazu¹,Suzuki Eriko¹,Hasumi Keiji¹³

Affiliation:

1. Department of Applied Biological Science, Tokyo University of Agriculture and Technology , Fuchu , Japan

2. Business Development Division, INTAGE Healthcare Inc. , Osaka , Japan

3. Department of Research and Development, TMS Co. , Fuchu , Japan

Abstract

ABSTRACT Soluble epoxide hydrolase (EC 3.3.2.10) is a key enzyme in the regulation of inflammation and metabolism, whereas, the role of its N-terminal phosphatase activity (N-phos) has been poorly understood because of a lack of selective inhibitors. Here we report 4-aminobenzoic (Ki 15.3 µm) and 3-amino-4-hydroxy benzoic acid (Ki 11.7 µm) as selective competitive inhibitors of N-phos.

Funder

Japan Society for the Promotion of Science

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbad016/49294140/zbad016.pdf

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