Sarcomatoid transformation of a basal cell carcinoma following treatment with hedgehog inhibitors

Author:

Barrabés-Torrella Cristina1ORCID,Arandes-Marcocci Jorge1,Armillas-Lliteras Lucia1,Posada-Caez Rodolfo A1,Koptseva Inessa1,Fumagalli Caterina2,Piñol-Ballús David2,Salleras-Redonnet Montse1

Affiliation:

1. Department of Dermatology and Pathology, Hospital Universitari Sagrat Cor, Grupo Hospitalario Quirónsalud

2. Department of Pathology, Hospital de la Santa Creu i Sant Pau , Barcelona , Spain

Abstract

Vismodegib and sonidegib are sonic hedgehog inhibitors (SHHIs) available for the treatment of advanced basal cell carcinoma (BCC). Cases of sarcomatoid differentiation during treatment of BCC with SHHIs have not been previously reported. We present a unique case of a locally advanced BCC that underwent sarcomatoid transformation, manifesting as a large mass complicated by local invasion and lung metastases, following treatment with sonidegib.

Publisher

Oxford University Press (OUP)

Subject

Dermatology

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