Combined use of nivolumab and ipilimumab in Japanese patients with melanoma: a multicentre retrospective study of 111 cases-Reference-Cited by-全球学者库

Combined use of nivolumab and ipilimumab in Japanese patients with melanoma: a multicentre retrospective study of 111 cases

Published:2023-04-05 Issue:2 Volume:189 Page:223-250
ISSN:0007-0963
Container-title:British Journal of Dermatology
language:en
Short-container-title:

Author:

Fujisawa Yasuhiro¹²^ORCID,Namikawa Kenjiro³^ORCID,Yoshino Koji⁴,Kiniwa Yukiko⁵,Ito Takamichi⁶,Kato Hiroshi⁷,Matsushita Shigeto⁸,Hoashi Toshihiko,Nakamura Yasuhiro,Yoshikawa Shusuke,Miyagawa Takuya,Asai Jun,Matsuya Taisuke,Fukushima Satoshi,Kato Jyunji,Takenouchi Tatsuya,Uchi Hiroshi,Masuzawa Mamiko,Yanagi Teruki,Maekawa Takeo

Affiliation:

1. Department of Dermatology, University of Tsukuba , Tsukuba

2. Department of Dermatology, Ehime University, To-on

3. Department of Dermatologic Oncology, National Cancer Center Hospital , Tokyo

4. Dermatologic Oncology/Dermatology, The Cancer Institute Hospital of Japanese Foundation for Cancer Research , Tokyo

5. Department of Dermatology, Shinshu University , Matsumoto

6. Department of Dermatology, Kyushu University , Fukuoka

7. Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences , Nagoya

8. Department of Dermato-Oncology/Dermatology, National Hospital Organization Kagoshima Medical Center , Kagoshima , Japan

Abstract

In Japanese patients with melanoma, the response rate of nivolumab plus ipilimumab (N/I) was lower than (35.1%) and the rate of adverse events was similar to (60.4%) those reported in previous clinical trials. No survival difference was observed with the use of N/I between clinical types. Patients who achieved a good response had better outcomes. Elevated lactate dehydrogenase level and having three or more metastatic sites were poor prognostic factors.

Funder

National Cancer Center Research and Development Fund

Publisher

Oxford University Press (OUP)

Subject

Dermatology

Link

https://academic.oup.com/bjd/advance-article-pdf/doi/10.1093/bjd/ljad114/50646278/ljad114.pdf

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