Associations between evening shift work, irregular sleep timing, and gestational diabetes in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b)

Author:

Wallace Danielle A12ORCID,Reid Kathryn3,Grobman William A4,Facco Francesca L5,Silver Robert M6,Pien Grace W7,Louis Judette8,Zee Phyllis C3,Redline Susan129ORCID,Sofer Tamar1210ORCID

Affiliation:

1. Division of Sleep Medicine, Harvard Medical School , Boston MA , USA

2. Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital , Boston MA , USA

3. Department of Neurology and Center for Circadian and Sleep Medicine, Northwestern University Feinberg School of Medicine , Chicago, IL , USA

4. Department of Obstetrics and Gynecology, The Ohio State University College of Medicine , Columbus, OH , USA

5. Department of Obstetrics and Gynecology, University of Pittsburgh, Magee-Womens Hospital , Pittsburgh, PA , USA

6. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center , Salt Lake City, UT , USA

7. Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine , Baltimore, MD , USA

8. Department of Obstetrics and Gynecology, University of South Florida Morsani College of Medicine , Tampa, FL , USA

9. Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA , USA

10. Department of Biostatistics, Harvard T.H. Chan School of Public Health , Boston, MA , USA

Abstract

Abstract Study Objectives Shift work is a risk factor for cardiometabolic disease, possibly through effects on sleep–wake rhythms. We hypothesized that evening (afternoon and night combined) and irregular (irregular/on-call or rotating combined) shift work during pregnancy is associated with increased odds of preeclampsia, preterm birth, and gestational diabetes mellitus (GDM), mediated by irregular sleep timing. Methods The Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b) is a prospective cohort study (n = 10 038) designed to investigate risk factors for adverse pregnancy outcomes. Medical outcomes were determined with medical record abstraction and/or questionnaires; sleep midpoint was measured in a subset of participants with ≥5-day wrist actigraphy (ActiWatch). We estimated the association of evening and irregular shift work during pregnancy with preeclampsia, preterm birth, and GDM using logistic regression, adjusted for adversity (cumulative variable for poverty, education, health insurance, and partner status), smoking, self-reported race/ethnicity, and age. Finally, we explored whether the association between shiftwork and GDM was mediated by variability in sleep timing. Results Evening shift work is associated with approximately 75% increased odds of developing GDM (adjusted OR = 1.75, 95% CI: 1.12–2.66); we did not observe associations with irregular shifts, preterm birth, or preeclampsia after adjustment. Pregnant evening shift workers were found to have approximately 45 minutes greater variability in sleep timing compared to day workers (p < .005); sleep-timing variability explained 25% of the association between evening shift work and GDM in a mediation analysis. Conclusions Evening shift work was associated with GDM, and this relationship may be mediated by variability in sleep timing.

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Neurology (clinical)

Reference63 articles.

1. A time to work: recent trends in shift work and flexible schedules.;McMenamin;Mon Labor Rev,2007

2. Night shift work, genetic risk, and type 2 diabetes in the UK biobank;Vetter;Diabetes Care.,2018

3. Association between shift work and risk of type 2 diabetes mellitus: a systematic review and dose-response meta-analysis of observational studies;Gao;Chronobiol Int.,2020

4. Shift work, and particularly permanent night shifts, promote dyslipidaemia: A systematic review and meta-analysis;Dutheil;Atherosclerosis,2020

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