Impact of nanosystems in Staphylococcus aureus biofilms treatment

Author:

Pinto Rita M1234,Lopes-de-Campos Daniela1,Martins M Cristina L45,Van Dijck Patrick23ORCID,Nunes Cláudia1,Reis Salette1

Affiliation:

1. LAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal

2. Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, B-3001 Leuven, Belgium

3. VIB-KU Leuven, Center for Microbiology, B-3001 Leuven, Belgium

4. i3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto; INEB, Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal

5. ICBAS, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal

Abstract

ABSTRACT Staphylococcus aureus (S. aureus) is considered by the World Health Organization as a high priority pathogen for which new therapies are needed. This is particularly important for biofilm implant-associated infections once the only available treatment option implies a surgical procedure combined with antibiotic therapy. Consequently, these infections represent an economic burden for Healthcare Systems. A new strategy has emerged to tackle this problem: for small bugs, small particles. Here, we describe how nanotechnology-based systems have been studied to treat S. aureus biofilms. Their features, drawbacks and potentialities to impact the treatment of these infections are highlighted. Furthermore, we also outline biofilm models and assays required for preclinical validation of those nanosystems to smooth the process of clinical translation.

Funder

Fundação para a Ciência e Tecnologia

Programa Operacional Capital Humano

BiotechHealth Programme

Scientific Research Flanders

Fundo Europeu de Desenvolvimento Regional

Operational Programme for Competitiveness and Internationalisation

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology

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