A search for food extracts inhibiting ferroptosis using immortalized mouse embryonic fibroblasts derived from xCT knockout mice-Reference-Cited by-同舟云学术

A search for food extracts inhibiting ferroptosis using immortalized mouse embryonic fibroblasts derived from xCT knockout mice

Published:2024-06-27 Issue:9 Volume:88 Page:1064-1068
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Mori Yasushi¹²,Abe Tsukumo¹,Masaya Nami¹,Igarashi Kiharu¹,Sato Hideyo³,Kobayashi Sho¹²^ORCID

Affiliation:

1. Department of Food, Life and Environmental Science, Faculty of Agriculture, Yamagata University , Tsuruoka, Yamagata , Japan

2. Laboratory of Food and Nutritional Science, Graduate School of Agricultural Science, Yamagata University , Tsuruoka, Yamagata , Japan

3. Laboratory of Biochemistry and Molecular Biology, Department of Medical Technology, Faculty of Medicine, Niigata University , Chuo-ku, Niigata , Japan

Abstract

Abstract Depleting glutathione by xCT inhibition induces iron-dependent ferroptotic cell death, which is suppressed by lipophilic antioxidants. We screened food extracts with xCTKO-MEFs, identifying garlic extracts as particularly potent in inhibiting ferroptosis among the food extracts examined in this study. xCTKO-MEFs can serve as a convenient tool for identifying food extracts that are effective in inhibiting ferroptosis.

Funder

JSPS

Yamagata University

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbae090/58588497/zbae090.pdf

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