An algorithm to personalise the diagnosis of recurrent implantation failure based on theoretical cumulative implantation rate

Author:

Rozen Genia123ORCID,Rogers Peter2,Teh Wan Tinn123,Stern Catharyn J123,Polyakov Alex123

Affiliation:

1. Reproductive Services, Royal Women’s Hospital, Parkville, VIC, Australia

2. Department of Obstetrics and Gynaecology, University of Melbourne, Gynaecology Research Centre, Royal Women's Hospital, Parkville, VIC, Australia

3. Melbourne IVF, East Melbourne, VIC, Australia

Abstract

Abstract Recurrent implantation failure (RIF) is an imprecisely defined disorder lacking a robust scientific basis. The incomplete understanding of RIF provides significant diagnostic and therapeutic challenges, and a better understanding of the underlying issues is necessary to improve outcomes. We propose a novel concept termed ‘Theoretical Cumulative Implantation Rate’, the calculation of which is based on objective data, to define whether a patient should be diagnosed with RIF. An updated definition to assist with patient counselling and planning research studies, which is more precise and standardised, is well overdue.

Publisher

Oxford University Press (OUP)

Subject

Obstetrics and Gynaecology,Rehabilitation,Reproductive Medicine

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