1. Institute for Molecular Medicine Finland , FIMM, HiLIFE, , Helsinki, Finland
2. University of Helsinki , FIMM, HiLIFE, , Helsinki, Finland
3. Department of Pulmonology, University of Helsinki and Helsinki University Hospital , Helsinki, Finland
4. Department of Anesthesia , Critical Care and Pain Medicine, , Boston, MA, USA
5. Massachusetts General Hospital and Harvard Medical School , Critical Care and Pain Medicine, , Boston, MA, USA
6. Program in Medical and Population Genetics, Broad Institute , Cambridge, MA, USA