Design, fabrication and clinical characterization of additively manufactured tantalum hip joint prosthesis

Author:

Zhao Dewei1ORCID,Cheng Liangliang1,Lu Faqiang1,Zhang Xiuzhi1,Ying Jiawei1,Wei Xiaowei1,Cao Fang1,Ran Chunxiao1,Zheng Guoshuang1,Liu Ge1,Yi Pinqiao1,Wang Haiyao1,Song Liqun1,Wu Bin1,Liu Lingpeng1,Li Lu1,Wang Xiaohu1,Li Junlei1

Affiliation:

1. Department of Orthopaedics, Affiliated Zhongshan Hospital of Dalian University , Dalian 116001, China

Abstract

Abstract The joint prosthesis plays a vital role in the outcome of total hip arthroplasty. The key factors that determine the performance of joint prostheses are the materials used and the structural design of the prosthesis. This study aimed to fabricate a porous tantalum (Ta) hip prosthesis using selective laser melting (SLM) technology. The feasibility of SLM Ta use in hip prosthesis was verified by studying its chemical composition, metallographic structure and mechanical properties. In vitro experiments proved that SLM Ta exhibited better biological activities in promoting osteogenesis and inhibiting inflammation than SLM Ti6Al4V. Then, the topological optimization design of the femoral stem of the SLM Ta hip prosthesis was carried out by finite element simulation, and the fatigue performance of the optimized prosthesis was tested to verify the biomechanical safety of the prosthesis. A porous Ta acetabulum cup was also designed and fabricated using SLM. Its mechanical properties were then studied. Finally, clinical trials were conducted to verify the clinical efficacy of the SLM Ta hip prosthesis. The porous structure could reduce the weight of the prosthesis and stress shielding and avoid bone resorption around the prosthesis. In addition, anti-infection drugs can also be loaded into the pores for infection treatment. The acetabular cup can be custom-designed based on the severity of bone loss on the acetabular side, and the integrated acetabular cup can repair the acetabular bone defect while achieving the function of the acetabular cup.

Funder

National Natural Science Foundation of China

LiaoNing Revitalization Talents Program

Publisher

Oxford University Press (OUP)

Reference47 articles.

1. Hip replacement;Ferguson;Lancet,2018

2. Artificial hip joints: the biomaterials challenge;Pezzotti;J Mech Behav Biomed Mater,2014

3. Porous tantalum in hip and knee reconstructive surgery;Patil;J Biomed Mater Res B Appl Biomater,2009

4. Hip prosthesis design. Market analysis, new perspectives and an innovative solution;Fiorentino;Proc Cirp,2013

5. Fixation of hip prostheses by hydroxyapatite ceramic coatings;Furlong;J Bone Joint Surg Br,1991

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3