An obituary on DAV-132—authors’ viewpoint on the current limits of pivotal trials in clinical microbiome research

Author:

Vehreschild Maria J G T1,Biehl Lena M2,Dane Aaron3,de Kraker Marlieke E A4ORCID,Timbermont Leen5,van Werkhoven C Henri6

Affiliation:

1. Department of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University Frankfurt , Frankfurt am Main , Germany

2. Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne , Cologne , Germany

3. Danestat Consulting Limited , Macclesfield , UK

4. Infection Control Program, Geneva University Hospitals and Faculty of Medicine , Geneva , Switzerland

5. Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp , Antwerp , Belgium

6. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University , Utrecht , the Netherlands

Funder

European Federation of Pharmaceutical Industries and Associations

EFPIA

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Microbiology (medical)

Reference12 articles.

1. Superbugs and superdrugs—SMi’s 12th annual conference—overcoming resistance. 17–18 March 2010, London, UK;Oni;IDrugs,2010

2. Targeted adsorption of molecules in the colon with the novel adsorbent-based medicinal product, DAV132: a proof of concept study in healthy subjects;de Gunzburg;J Clin Pharmacol,2015

3. An open randomized multicentre Phase 2 trial to assess the safety of DAV132 and its efficacy to protect gut microbiota diversity in hospitalized patients treated with fluoroquinolones;Vehreschild;J Antimicrob Chemother,2022

4. The potential impact of gut microbiota on your health: current status and future challenges;Sirisinha;Asian Pac J Allergy Immunol,2016

5. Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics;van Werkhoven;Nat Commun,2021

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