Affiliation:
1. Institue of Bioinformatics, University of Muenster, Germany
2. Department of Computational Biology and Medical Sciences, The University of Tokyo, Kashiwa, Japan
3. Laboratory of Systems Genomics, Department of Computational Biology and Medical Sciences, The University of Tokyo, Kashiwa, Japan
Abstract
Abstract
Ezrin, radixin, moesin, and merlin are cytoskeletal proteins, whose functions are specific to metazoans. They participate in cell cortex rearrangement, including cell–cell contact formation, and play an important role in cancer progression. Here, we have performed a comprehensive phylogenetic analysis of the proteins spanning 87 species. The results describe a possible mechanism for the protein family origin in the root of Metazoa, paralogs diversification in vertebrates, and acquisition of novel functions, including tumor suppression. In addition, a merlin paralog, present in most vertebrates but lost in mammals, has been described here for the first time. We have also highlighted a set of amino acid variations within the conserved motifs as the candidates for determining physiological differences between ERM paralogs.
Publisher
Oxford University Press (OUP)
Subject
Genetics,Ecology, Evolution, Behavior and Systematics
Reference78 articles.
1. The revised classification of eukaryotes eukaryotic microbiology;Adl;J Eukaryot Microbiol,2012
2. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs;Altschul;Nucleic Acids Res,1997
3. MEME SUITE: tools for motif discovery and searching;Bailey;Nucleic Acids Res,2009
4. FERM family proteins and their importance in cellular movements and wound healing (Review);Bosanquet;Int J Mol Med,2014
5. Normal membrane localization and actin association of the NF2 tumor suppressor protein are dependent on folding of its N-terminal domain;Brault;J Cell Sci,2001
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