The innate immune perspective of autoimmune and autoinflammatory conditions

Author:

Frizinsky Shirly1,Haj-Yahia Soad12,Machnes Maayan Diti12,Lifshitz Yulia12,Maoz-Segal Ramit12,Offengenden Irean1,Kidon Mona12,Agmon-Levin Nancy12

Affiliation:

1. Clinical Immunology, Angioedema and Allergy Unit, The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel

2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Abstract

Abstract Innate immunity is one of two immune defence system arms. It is present at birth and does not require ‘learning’ through exposure to foreign organisms. It activates various mechanisms collectively to eliminate pathogens and hold an infection until the adaptive response are mounted. The innate immune system consists of four elements: the epithelial barrier, cells (e.g. macrophages, NK cells), plasma proteins (e.g. complement) and cytokines. These components act in concert to induce complex processes, as well as recruitment, activation and differentiation of adaptive responses. The innate response is more than just the ‘first line of defence’, as it essentially withholds the vast majority of any intruder, has a complex interplay with the adaptive arm and is crucial for survival of the host. Finally, yet importantly, a myriad of diseases has been linked with innate immune dysregulation. In this mini-review we will shed some light on these conditions, particularly regarding autoinflammatory ones.

Funder

Sobi

Publisher

Oxford University Press (OUP)

Subject

Pharmacology (medical),Rheumatology

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