Outcomes and resource usage of infants born at ≤ 25 weeks gestation in Canada

Author:

Shafey Amy1,Bashir Rani Ameena2,Shah Prakesh13,Synnes Anne4,Yang Junmin3,Kelly Edmond N1, ,Shah Prakesh S,Harrison Adele,Synnes Anne,Ting Joseph,Yee Wendy,Aziz Khalid,Toye Jennifer,Fajardo Carlos,Kalapesi Zarin,Sankaran Koravangattu,Daspal Sibasis,Seshia Mary,Alvaro Ruben,Shivananda Sandesh,Da Silva Orlando,Nwaesei Chuks,Lee Kyong-Soon,Dunn Michael,Lemyre Brigitte,Dow Kimberly,Pelausa Ermelinda,Barrington Keith,Drolet Christine,Piedboeuf Bruno,Claveau Martine,Faucher Daniel,Bertelle Valerie,Masse Edith,Canning Roderick,Makary Hala,Ojah Cecil,Monterrosa Luis,Deshpandey Akhil,Afifi Jehier,Kajetanowicz Andrzej,Lee Shoo K,Pillay Thevanisha,Synnes Anne,Sauvé Reg,Hendson Leonora,Reichert Amber,Bodani Jaya,Sankaran Koravangattu,Moddemann Diane,Nwaesei Chuks,Daboval Thierry,Dow Kimberly,Lee David,Ly Linh,Kelly Edmond,el Helou Salhab,Church Paige,Pelausa Ermelinda,Riley Patricia,Levebrve Francine,Demers Charlotte,Bélanger Sylvie,Canning Roderick,Monterrosa Luis,Makary Hala,Vincer Michael,Murphy Phil

Affiliation:

1. Department of Pediatrics, University of Toronto, Toronto, Ontario

2. Department of Pediatrics, the University of Calgary, Calgary, Alberta

3. Maternal-Infant Care Research Center, Mount Sinai Hospital, Toronto, Ontario

4. Department of Pediatrics, University of British Columbia, Vancouver, British Columbia

Abstract

ABSTRACT Objectives To determine the outcomes and resource usage of infants born at ≤ 25 weeks gestational age (GA). Methods Retrospective study of infants born between April 2009 and September 2011 at ≤ 25 weeks’ GA in all neonatal intensive care units in Canada with follow-up in the neonatal follow-up clinics. Short-term morbidities, neurodevelopmental impairment, significant neurodevelopmental impairment, and resource utilization of infants born at ≤ 24 weeks were compared with neonates born at 25 weeks. Results Of 803 neonates discharged alive, 636 (80.4%) infants born at ≤ 25 weeks’ GA were assessed at 18 to 24 months. Caesarean delivery, lower birth weight, and less antenatal steroid exposure were more common in infants born ≤ 24 weeks as compared with 25 weeks. They had significantly higher incidences of ductus arteriosus ligation, severe intracranial hemorrhage, retinopathy of prematurity as well as longer length of stay, central line days, days on respiratory support, days on total parenteral nutrition, days on antibiotics, and need for postnatal steroids. Neurodevelopmental impairment rates were 68.9, 64.5, and 55.6% (P=0.01) and significant neurodevelopmental impairment rates were 39.3, 29.6, and 20.9% (P<0.01) for infants ≤ 23, 24, and 25 weeks GA, respectively. Postdischarge service referrals were higher for those ≤ 23 weeks. Nonsurviving infants born at 25 weeks GA had higher resource utilization during admission than infants born less than 25 weeks. Conclusions Adverse outcomes and resource usage were significantly higher among infants born ≤ 24 weeks GA as compared with 25 weeks GA.

Funder

Maternal-Infant Care Research Centre

Canadian Institutes of Health Research

Publisher

Oxford University Press (OUP)

Subject

Pediatrics, Perinatology, and Child Health

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3