The UCSC Genome Browser database: 2018 update-Reference-Cited by-同舟云学术

The UCSC Genome Browser database: 2018 update

Published:2017-11-02 Issue:D1 Volume:46 Page:D762-D769
ISSN:0305-1048
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Casper Jonathan¹,Zweig Ann S¹,Villarreal Chris¹,Tyner Cath¹,Speir Matthew L¹,Rosenbloom Kate R¹,Raney Brian J¹,Lee Christopher M¹,Lee Brian T¹^ORCID,Karolchik Donna¹,Hinrichs Angie S¹,Haeussler Maximilian¹,Guruvadoo Luvina¹,Navarro Gonzalez Jairo¹,Gibson David¹,Fiddes Ian T¹,Eisenhart Christopher¹,Diekhans Mark¹,Clawson Hiram¹,Barber Galt P¹,Armstrong Joel¹,Haussler David¹²,Kuhn Robert M¹,Kent W James¹

Affiliation:

1. Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA

2. Howard Hughes Medical Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA

Abstract

Abstract The UCSC Genome Browser (https://genome.ucsc.edu) provides a web interface for exploring annotated genome assemblies. The assemblies and annotation tracks are updated on an ongoing basis—12 assemblies and more than 28 tracks were added in the past year. Two recent additions are a display of CRISPR/Cas9 guide sequences and an interactive navigator for gene interactions. Other upgrades from the past year include a command-line version of the Variant Annotation Integrator, support for Human Genome Variation Society variant nomenclature input and output, and a revised highlighting tool that now supports multiple simultaneous regions and colors.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

http://academic.oup.com/nar/article-pdf/46/D1/D762/33043750/gkx1020.pdf

Reference47 articles.

1. The Human Genome Browser at UCSC;Kent;Genome Res.,2002

2. Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR;Haeussler;Genome Biol.,2016

3. Microhomology-based choice of Cas9 nuclease target sites;Bae;Nat. Methods,2014

4. CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo;Moreno-Mateos;Nat. Methods,2015

5. Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9;Doench;Nat. Biotechnol.,2016

Cited by 433 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pan-cancer multi-omics analysis reveals the prognostic value of RGS gene family;2024-01-08

2. Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human;Nature Genetics;2024-01

3. Yeast zinc cluster transcription factors involved in the switch from fermentation to respiration show interdependency for DNA binding revealing a novel type of DNA recognition;Nucleic Acids Research;2023-12-18

4. Molecular identification of missense variants in SLC3A1 gene; an approach leading to computer-aided drug design for cystinuria;Gene;2023-12

5. Multi-level characteristics recognition of cancer core therapeutic targets and drug screening for a broader patient population;Frontiers in Pharmacology;2023-11-23