Abnormal dynamics of resting-state functional activity and couplings in postpartum depression with and without anxiety

Author:

Cheng Bochao123ORCID,Wang Xiuli45,Roberts Neil6,Zhou Yushan78910,Wang Song910,Deng Pengcheng12,Meng Yajing118,Deng Wei118,Wang Jiaojian1213ORCID

Affiliation:

1. Department of Radiology , , Chengdu 610041 , China

2. West China Second University Hospital of Sichuan University , , Chengdu 610041 , China

3. Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education , Chengdu 610041 , China

4. Department of Psychiatry , The Fourth People’s Hospital of Chengdu, , Chengdu 610041 , China

5. University of Electronic Science and Technology of China , The Fourth People’s Hospital of Chengdu, , Chengdu 610041 , China

6. Edinburgh Imaging facility, The Queen's Medical Research Institute (QMRI), School of Clinical Sciences, University of Edinburgh , Edinburgh EH16 4TJ , United Kingdom

7. Department of Nuclear Medicine , , Chengdu 610041 , China

8. West China Hospital of Sichuan University , , Chengdu 610041 , China

9. Huaxi MR Research Center (HMRRC) , Department of Radiology, , Chengdu 610041 , China

10. West China Hospital of Sichuan University , Department of Radiology, , Chengdu 610041 , China

11. Department of Psychiatry , , Chengdu 610041 , China

12. State Key Laboratory of Primate Biomedical Research , Institute of Primate Translational Medicine, , Kunming 650500 , China

13. Kunming University of Science and Technology , Institute of Primate Translational Medicine, , Kunming 650500 , China

Abstract

Abstract Postpartum depression (PPD) and PPD comorbid with anxiety (PPD-A) are highly prevalent and severe mental health problems in postnatal women. PPD and PPD-A share similar pathopsychological features, leading to ongoing debates regarding the diagnostic and neurobiological uniqueness. This paper aims to delineate common and disorder-specific neural underpinnings and potential treatment targets for PPD and PPD-A by characterizing functional dynamics with resting-state functional magnetic resonance imaging in 138 participants (45 first-episode, treatment-naïve PPD; 31 PDD-A patients; and 62 healthy postnatal women [HPW]). PPD-A group showed specifically increased dynamic amplitude of low-frequency fluctuation in the subgenual anterior cingulate cortex (sgACC) and increased dynamic functional connectivity (dFC) between the sgACC and superior temporal sulcus. PPD group exhibited specifically increased static FC (sFC) between the sgACC and ventral anterior insula. Common disrupted sFC between the sgACC and middle temporal gyrus was found in both PPD and PPD-A patients. Interestingly, dynamic changes in dFC between the sgACC and superior temporal gyrus could differentiate PPD, PPD-A, and HPW. Our study presents initial evidence on specifically abnormal functional dynamics of limbic, emotion regulation, and social cognition systems in patients with PDD and PPD-A, which may facilitate understanding neurophysiological mechanisms, diagnosis, and treatment for PPD and PPD-A.

Funder

Chinese National Natural Science Foundation

Sichuan Science and Technology Program

National Key Technology R&D Program of the Ministry of Science and Technology of China

Scientific research project of Sichuan health planning committee

National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

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