Adolescent Binge Drinking Is Associated With Accelerated Decline of Gray Matter Volume

Author:

Infante M A1,Eberson S C1ORCID,Zhang Y23,Brumback T4,Brown S A15,Colrain I M6,Baker F C6,Clark D B7,De Bellis M D8,Goldston D8,Nagel B J9,Nooner K B10,Zhao Q11,Pohl K M611,Sullivan E V11ORCID,Pfefferbaum A611,Tapert S F1,Thompson W K2312

Affiliation:

1. Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA

2. Division of Biostatistics, Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, USA

3. Population Neuroscience and Genetics Lab, University of California, San Diego, USA

4. Department of Psychological Science, Northern Kentucky University, Kentucky, USA

5. Department of Psychology, University of California, San Diego, La Jolla, CA, USA

6. Center for Health Sciences, SRI International, Menlo Park, CA, USA

7. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA

8. Department of Psychiatry & Behavioral Sciences, Duke University, Durham, NC, USA

9. Departments of Psychiatry and Behavioral Neuroscience, Oregon Health & Sciences University, Portland, OR, USA

10. Department of Psychology, University of North Carolina Wilmington, Wilmington, NC, USA

11. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA

12. Department of Radiology, University of California, San Diego, USA

Abstract

Abstract The age- and time-dependent effects of binge drinking on adolescent brain development have not been well characterized even though binge drinking is a health crisis among adolescents. The impact of binge drinking on gray matter volume (GMV) development was examined using 5 waves of longitudinal data from the National Consortium on Alcohol and NeuroDevelopment in Adolescence study. Binge drinkers (n = 166) were compared with non-binge drinkers (n = 82 after matching on potential confounders). Number of binge drinking episodes in the past year was linked to decreased GMVs in bilateral Desikan–Killiany cortical parcellations (26 of 34 with P < 0.05/34) with the strongest effects observed in frontal regions. Interactions of binge drinking episodes and baseline age demonstrated stronger effects in younger participants. Statistical models sensitive to number of binge episodes and their temporal proximity to brain volumes provided the best fits. Consistent with prior research, results of this study highlight the negative effects of binge drinking on the developing brain. Our results present novel findings that cortical GMV decreases were greater in closer proximity to binge drinking episodes in a dose–response manner. This relation suggests a causal effect and raises the possibility that normal growth trajectories may be reinstated with alcohol abstinence.

Funder

U.S. National Institute on Alcohol Abuse and Alcoholism

National Institutes of Health

National Institute on Drug Abuse

National Institute of Mental Health

National Institute of Child Health and Human Development

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

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