Individual Variability in Functional Organization of the Human and Monkey Auditory Cortex

Author:

Ren Jianxun12,Xu Ting3,Wang Danhong2,Li Meiling2,Lin Yuanxiang4,Schoeppe Franziska2,Ramirez Julian S B5,Han Ying6,Luan Guoming7,Li Luming189,Liu Hesheng210,Ahveninen Jyrki2

Affiliation:

1. National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, 100084 Beijing, China

2. Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA

3. Center for the Developing Brain, Child Mind Institute, New York, NY 10022, USA

4. Department of Neurosurgery, First Affiliated Hospital, Fujian Medical University, 350108 Fuzhou, China

5. Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA

6. Department of Neurology, Xuanwu Hospital of Capital Medical University, 100053 Beijing, China

7. Department of Neurosurgery, Comprehensive Epilepsy Center, Sanbo Brain Hospital, Capital Medical University, 100093 Beijing, China

8. Precision Medicine & Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, 518055 Shenzhen, China

9. IDG/McGovern Institute for Brain Research, Tsinghua University, 100084 Beijing, China

10. Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA

Abstract

Abstract Accumulating evidence shows that auditory cortex (AC) of humans, and other primates, is involved in more complex cognitive processes than feature segregation only, which are shaped by experience-dependent plasticity and thus likely show substantial individual variability. However, thus far, individual variability of ACs has been considered a methodological impediment rather than a phenomenon of theoretical importance. Here, we examined the variability of ACs using intrinsic functional connectivity patterns in humans and macaques. Our results demonstrate that in humans, interindividual variability is greater near the nonprimary than primary ACs, indicating that variability dramatically increases across the processing hierarchy. ACs are also more variable than comparable visual areas and show higher variability in the left than in the right hemisphere, which may be related to the left lateralization of auditory-related functions such as language. Intriguingly, remarkably similar modality differences and lateralization of variability were also observed in macaques. These connectivity-based findings are consistent with a confirmatory task-based functional magnetic resonance imaging analysis. The quantification of variability in auditory function, and the similar findings in both humans and macaques, will have strong implications for understanding the evolution of advanced auditory functions in humans.

Funder

Shenzhen International Cooperative Research Project

National Institutes of Health

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

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